Next Article in Journal
Chitosan Hydrochloride Decreases Fusarium graminearum Growth and Virulence and Boosts Growth, Development and Systemic Acquired Resistance in Two Durum Wheat Genotypes
Next Article in Special Issue
The Optimization of a Novel Hydrogel—Egg White-Alginate for 2.5D Tissue Engineering of Salivary Spheroid-Like Structure
Previous Article in Journal
Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds
Previous Article in Special Issue
Small Physical Cross-Linker Facilitates Hyaluronan Hydrogels
Open AccessArticle

Numerical Simulations as Means for Tailoring Electrically Conductive Hydrogels towards Cartilage Tissue Engineering by Electrical Stimulation

1
Institute of General Electrical Engineering, University of Rostock, 18051 Rostock, Germany
2
Institute of Biomaterials, Friedrich Alexander University Erlangen-Nuremberg, 91058 Erlangen, Germany
3
Department Life, Light & Matter, University of Rostock, 18051 Rostock, Germany
4
Department of Ageing of Individuals and Society, Interdisciplinary Faculty, University of Rostock, 18051 Rostock, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Roberta Cassano
Molecules 2020, 25(20), 4750; https://doi.org/10.3390/molecules25204750
Received: 30 July 2020 / Revised: 11 September 2020 / Accepted: 6 October 2020 / Published: 16 October 2020
(This article belongs to the Special Issue Hydrogels for Tissue Engineering and Regenerative Medicine)
Cartilage regeneration is a clinical challenge. In recent years, hydrogels have emerged as implantable scaffolds in cartilage tissue engineering. Similarly, electrical stimulation has been employed to improve matrix synthesis of cartilage cells, and thus to foster engineering and regeneration of cartilage tissue. The combination of hydrogels and electrical stimulation may pave the way for new clinical treatment of cartilage lesions. To find the optimal electric properties of hydrogels, theoretical considerations and corresponding numerical simulations are needed to identify well-suited initial parameters for experimental studies. We present the theoretical analysis of a hydrogel in a frequently used electrical stimulation device for cartilage regeneration and tissue engineering. By means of equivalent circuits, finite element analysis, and uncertainty quantification, we elucidate the influence of the geometric and dielectric properties of cell-seeded hydrogels on the capacitive-coupling electrical field stimulation. Moreover, we discuss the possibility of cellular organisation inside the hydrogel due to forces generated by the external electric field. The introduced methodology is easily reusable by other researchers and allows to directly develop novel electrical stimulation study designs. Thus, this study paves the way for the design of future experimental studies using electrically conductive hydrogels and electrical stimulation for tissue engineering. View Full-Text
Keywords: electrical stimulation; electrically conductive hydrogels; tissue engineering; scaffold; computational modelling; uncertainty quantification; capacitive coupling; finite element analysis; biomaterial scaffolds electrical stimulation; electrically conductive hydrogels; tissue engineering; scaffold; computational modelling; uncertainty quantification; capacitive coupling; finite element analysis; biomaterial scaffolds
Show Figures

Figure 1

MDPI and ACS Style

Zimmermann, J.; Distler, T.; Boccaccini, A.R.; van Rienen, U. Numerical Simulations as Means for Tailoring Electrically Conductive Hydrogels towards Cartilage Tissue Engineering by Electrical Stimulation. Molecules 2020, 25, 4750. https://doi.org/10.3390/molecules25204750

AMA Style

Zimmermann J, Distler T, Boccaccini AR, van Rienen U. Numerical Simulations as Means for Tailoring Electrically Conductive Hydrogels towards Cartilage Tissue Engineering by Electrical Stimulation. Molecules. 2020; 25(20):4750. https://doi.org/10.3390/molecules25204750

Chicago/Turabian Style

Zimmermann, Julius; Distler, Thomas; Boccaccini, Aldo R.; van Rienen, Ursula. 2020. "Numerical Simulations as Means for Tailoring Electrically Conductive Hydrogels towards Cartilage Tissue Engineering by Electrical Stimulation" Molecules 25, no. 20: 4750. https://doi.org/10.3390/molecules25204750

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop