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Molecular Sensing with Host Systems for Hyperpolarized 129Xe

Molecular Imaging, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany
Author to whom correspondence should be addressed.
Academic Editor: Danila Barskiy
Molecules 2020, 25(20), 4627;
Received: 31 August 2020 / Revised: 27 September 2020 / Accepted: 30 September 2020 / Published: 11 October 2020
Hyperpolarized noble gases have been used early on in applications for sensitivity enhanced NMR. 129Xe has been explored for various applications because it can be used beyond the gas-driven examination of void spaces. Its solubility in aqueous solutions and its affinity for hydrophobic binding pockets allows “functionalization” through combination with host structures that bind one or multiple gas atoms. Moreover, the transient nature of gas binding in such hosts allows the combination with another signal enhancement technique, namely chemical exchange saturation transfer (CEST). Different systems have been investigated for implementing various types of so-called Xe biosensors where the gas binds to a targeted host to address molecular markers or to sense biophysical parameters. This review summarizes developments in biosensor design and synthesis for achieving molecular sensing with NMR at unprecedented sensitivity. Aspects regarding Xe exchange kinetics and chemical engineering of various classes of hosts for an efficient build-up of the CEST effect will also be discussed as well as the cavity design of host molecules to identify a pool of bound Xe. The concept is presented in the broader context of reporter design with insights from other modalities that are helpful for advancing the field of Xe biosensors. View Full-Text
Keywords: xenon; Hyper-CEST; supramolecular complexes; biosensors; NMR; MRI xenon; Hyper-CEST; supramolecular complexes; biosensors; NMR; MRI
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MDPI and ACS Style

Jayapaul, J.; Schröder, L. Molecular Sensing with Host Systems for Hyperpolarized 129Xe. Molecules 2020, 25, 4627.

AMA Style

Jayapaul J, Schröder L. Molecular Sensing with Host Systems for Hyperpolarized 129Xe. Molecules. 2020; 25(20):4627.

Chicago/Turabian Style

Jayapaul, Jabadurai, and Leif Schröder. 2020. "Molecular Sensing with Host Systems for Hyperpolarized 129Xe" Molecules 25, no. 20: 4627.

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