Next Article in Journal
Conversion of CO2 into Chloropropene Carbonate Catalyzed by Iron (II) Phthalocyanine Hypercrosslinked Porous Organic Polymer
Next Article in Special Issue
Mimicking the Nucleosomal Context in Peptide-Based Binders of a H3K36me Reader Increases Binding Affinity While Altering the Binding Mode
Previous Article in Journal
Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A
Previous Article in Special Issue
Combined Protein- and Ligand-Observed NMR Workflow to Screen Fragment Cocktails against Multiple Proteins: A Case Study Using Bromodomains

NMR as a “Gold Standard” Method in Drug Design and Discovery

Core Labs, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
Biological and Environmental Sciences & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
Department of Chemistry, University of Alberta, Edmonton, AB T6G 2W2, Canada
Biology Department, Faculty of Science, Taibah University, Yanbu El-Bahr 46423, Saudi Arabia
Nanomedicine Department, Institute for Research and Medical, Consultations (IRMC), Imam Abdulrahman Bin Faisal University (IAU), Dammam 31441, Saudi Arabia
Department of Medical Sciences and Public Health, Università di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
Authors to whom correspondence should be addressed.
Academic Editor: Simona Golič Grdadolnik
Molecules 2020, 25(20), 4597;
Received: 22 September 2020 / Revised: 5 October 2020 / Accepted: 6 October 2020 / Published: 9 October 2020
(This article belongs to the Special Issue NMR in the Drug Design)
Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies. Microbial infections are still a major challenge because pathogens rapidly and continually evolve developing drug resistance. Cancer cells also change genetically, and current therapeutic techniques may be (or may become) ineffective in many cases. The pathology of many neurological diseases remains an enigma, and the exact etiology and underlying mechanisms are still largely unknown. Viral infections spread and develop much more quickly than does the corresponding research needed to prevent and combat these infections; the present and most relevant outbreak of SARS-CoV-2, which originated in Wuhan, China, illustrates the critical and immediate need to improve drug design and development techniques. Modern day drug discovery is a time-consuming, expensive process. Each new drug takes in excess of 10 years to develop and costs on average more than a billion US dollars. This demonstrates the need of a complete redesign or novel strategies. Nuclear Magnetic Resonance (NMR) has played a critical role in drug discovery ever since its introduction several decades ago. In just three decades, NMR has become a “gold standard” platform technology in medical and pharmacology studies. In this review, we present the major applications of NMR spectroscopy in medical drug discovery and development. The basic concepts, theories, and applications of the most commonly used NMR techniques are presented. We also summarize the advantages and limitations of the primary NMR methods in drug development. View Full-Text
Keywords: NMR; drug design; drug development; drug discovery; therapeutics NMR; drug design; drug development; drug discovery; therapeutics
Show Figures

Graphical abstract

MDPI and ACS Style

Emwas, A.-H.; Szczepski, K.; Poulson, B.G.; Chandra, K.; McKay, R.T.; Dhahri, M.; Alahmari, F.; Jaremko, L.; Lachowicz, J.I.; Jaremko, M. NMR as a “Gold Standard” Method in Drug Design and Discovery. Molecules 2020, 25, 4597.

AMA Style

Emwas A-H, Szczepski K, Poulson BG, Chandra K, McKay RT, Dhahri M, Alahmari F, Jaremko L, Lachowicz JI, Jaremko M. NMR as a “Gold Standard” Method in Drug Design and Discovery. Molecules. 2020; 25(20):4597.

Chicago/Turabian Style

Emwas, Abdul-Hamid; Szczepski, Kacper; Poulson, Benjamin G.; Chandra, Kousik; McKay, Ryan T.; Dhahri, Manel; Alahmari, Fatimah; Jaremko, Lukasz; Lachowicz, Joanna I.; Jaremko, Mariusz. 2020. "NMR as a “Gold Standard” Method in Drug Design and Discovery" Molecules 25, no. 20: 4597.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop