Next Article in Journal
Polyphenol Composition and Antioxidant Potential of Instant Gruels Enriched with Lycium barbarum L. Fruit
Next Article in Special Issue
Thuja occidentalis L. (Cupressaceae): Ethnobotany, Phytochemistry and Biological Activity
Previous Article in Journal
Aluminium Binding to Modified Amyloid-β Peptides: Implications for Alzheimer’s Disease
Previous Article in Special Issue
A Bioactive Olive Pomace Extract Prevents the Death of Murine Cortical Neurons Triggered by NMDAR Over-Activation
Review

Glucosinolates: Natural Occurrence, Biosynthesis, Accessibility, Isolation, Structures, and Biological Activities

1
URD Agro-Biotechnologies Industrielles (ABI), CEBB (Centre Européen de Biotechnologie et de Bioéconomie), AgroParisTech, 51110 Pomacle, France
2
Department of Chemistry, University of Florida, Gainesville, FL 326011, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Cristina Forzato
Molecules 2020, 25(19), 4537; https://doi.org/10.3390/molecules25194537
Received: 17 August 2020 / Revised: 28 September 2020 / Accepted: 28 September 2020 / Published: 3 October 2020
Glucosinolates (GSLs) are secondary plant metabolites abundantly found in plant order Brassicales. GSLs are constituted by an S-β-d-glucopyrano unit anomerically connected to O-sulfated (Z)-thiohydroximate moiety. The side-chain of the O-sulfate thiohydroximate moiety, which is derived from a different amino acid, contributes to the diversity of natural GSL, with more than 130 structures identified and validated to this day. Both the structural diversity of GSL and their biological implication in plants have been biochemically studied. Although chemical syntheses of GSL have been devised to give access to these secondary metabolites, direct extraction from biomass remains the conventional method to isolate natural GSL. While intact GSLs are biologically inactive, various products, including isothiocyanates, nitriles, epithionitriles, and cyanides obtained through their hydrolysis of GSLs, exhibit many different biological activities, among which several therapeutic benefits have been suggested. This article reviews natural occurrence, accessibility via chemical, synthetic biochemical pathways of GSL, and the current methodology of extraction, purification, and characterization. Structural information, including the most recent classification of GSL, and their stability and storage conditions will also be discussed. The biological perspective will also be explored to demonstrate the importance of these prominent metabolites. View Full-Text
Keywords: glucosinolates; myrosinases; Brassicaceae family; Moringacea family; Brassicales glucosinolates; myrosinases; Brassicaceae family; Moringacea family; Brassicales
Show Figures

Figure 1

MDPI and ACS Style

Nguyen, V.P.T.; Stewart, J.; Lopez, M.; Ioannou, I.; Allais, F. Glucosinolates: Natural Occurrence, Biosynthesis, Accessibility, Isolation, Structures, and Biological Activities. Molecules 2020, 25, 4537. https://doi.org/10.3390/molecules25194537

AMA Style

Nguyen VPT, Stewart J, Lopez M, Ioannou I, Allais F. Glucosinolates: Natural Occurrence, Biosynthesis, Accessibility, Isolation, Structures, and Biological Activities. Molecules. 2020; 25(19):4537. https://doi.org/10.3390/molecules25194537

Chicago/Turabian Style

Nguyen, V. P.T., Jon Stewart, Michel Lopez, Irina Ioannou, and Florent Allais. 2020. "Glucosinolates: Natural Occurrence, Biosynthesis, Accessibility, Isolation, Structures, and Biological Activities" Molecules 25, no. 19: 4537. https://doi.org/10.3390/molecules25194537

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop