Next Article in Journal
The Effect of Moisture on the Adhesion Energy and Nanostructure of Asphalt-Aggregate Interface System Using Molecular Dynamics Simulation
Next Article in Special Issue
Synthesis of Organosilicon Ligands for Europium (III) and Gadolinium (III) as Potential Imaging Agents
Previous Article in Journal
Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management
Previous Article in Special Issue
Colorimetry of Luminescent Lanthanide Complexes
Open AccessArticle

Luminescent Sensor Based on Ln(III) Ternary Complexes for NAD(P)H Detection

Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Eszter Borbas
Molecules 2020, 25(18), 4164; https://doi.org/10.3390/molecules25184164
Received: 31 July 2020 / Revised: 5 September 2020 / Accepted: 7 September 2020 / Published: 11 September 2020
(This article belongs to the Special Issue Luminescent Lanthanide Complexes)
Ln(III) complexes of macrocyclic ligands are used in medicinal chemistry, for example as contrast agents in MRI or radiopharmaceutical compounds, and in diagnostics using fluorescence imaging. This paper is devoted to a spectroscopic study of Ln(III) ternary complexes consisting of macrocyclic heptadentate DO3A and bidentate 3-isoquinolinate (IQCA) ligands. IQCA serves as an efficient antenna ligand, leading to a higher quantum yield and Stokes shift (250–350 nm for Eu, Tb, Sm, Dy in VIS region, 550–650 nm for Yb, Nd in NIR region). The shielding-quenching effect of NAD(P)H on the luminescence of the Ln(III) ternary complexes was investigated in detail and this phenomenon was utilized for the analytical determination of this compound. This general approach was verified through an enzymatic reaction during which the course of ethanol transformation catalyzed by alcohol-dehydrogenase (ADH) was followed by luminescence spectroscopy. This method can be utilized for selective and sensitive determination of ethanol concentration and/or ADH enzyme activity. This new analytical method can also be used for other enzyme systems coupled with NAD(P)H/NAD(P)+ redox pairs. View Full-Text
Keywords: Ln(III) complexes; macrocyclic ligands; Ln(III) luminescence in VIS/NIR range; antenna ligand; NAD(P)H determination; enzyme probe Ln(III) complexes; macrocyclic ligands; Ln(III) luminescence in VIS/NIR range; antenna ligand; NAD(P)H determination; enzyme probe
Show Figures

Figure 1

MDPI and ACS Style

Smrčka, F.; Lubal, P. Luminescent Sensor Based on Ln(III) Ternary Complexes for NAD(P)H Detection. Molecules 2020, 25, 4164. https://doi.org/10.3390/molecules25184164

AMA Style

Smrčka F, Lubal P. Luminescent Sensor Based on Ln(III) Ternary Complexes for NAD(P)H Detection. Molecules. 2020; 25(18):4164. https://doi.org/10.3390/molecules25184164

Chicago/Turabian Style

Smrčka, Filip; Lubal, Přemysl. 2020. "Luminescent Sensor Based on Ln(III) Ternary Complexes for NAD(P)H Detection" Molecules 25, no. 18: 4164. https://doi.org/10.3390/molecules25184164

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop