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Catechins as Tools to Understand the Molecular Basis of Neurodegeneration

1
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 4M1, Canada
2
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4M1, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Saverio Bettuzzi
Molecules 2020, 25(16), 3571; https://doi.org/10.3390/molecules25163571
Received: 23 June 2020 / Revised: 25 July 2020 / Accepted: 3 August 2020 / Published: 6 August 2020
(This article belongs to the Special Issue Catechins in Human Health)
Protein misfolding as well as the subsequent self-association and deposition of amyloid aggregates is implicated in the progression of several neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Modulators of amyloidogenic aggregation serve as essential tools to dissect the underlying molecular mechanisms and may offer insight on potential therapeutic solutions. These modulators include green tea catechins, which are potent inhibitors of amyloid aggregation. Although catechins often exhibit poor pharmacokinetic properties and bioavailability, they are still essential tools for identifying the drivers of amyloid aggregation and for developing other aggregation modulators through structural mimicry. As an illustration of such strategies, here we review how catechins have been used to map the toxic surfaces of oligomeric amyloid-like species and develop catechin-based phenolic compounds with enhanced anti-amyloid activity. View Full-Text
Keywords: Alzheimer’s Disease; amyloid beta; catechin; EGCG; NMR; α-synuclein Alzheimer’s Disease; amyloid beta; catechin; EGCG; NMR; α-synuclein
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MDPI and ACS Style

Martinez Pomier, K.; Ahmed, R.; Melacini, G. Catechins as Tools to Understand the Molecular Basis of Neurodegeneration. Molecules 2020, 25, 3571. https://doi.org/10.3390/molecules25163571

AMA Style

Martinez Pomier K, Ahmed R, Melacini G. Catechins as Tools to Understand the Molecular Basis of Neurodegeneration. Molecules. 2020; 25(16):3571. https://doi.org/10.3390/molecules25163571

Chicago/Turabian Style

Martinez Pomier, Karla; Ahmed, Rashik; Melacini, Giuseppe. 2020. "Catechins as Tools to Understand the Molecular Basis of Neurodegeneration" Molecules 25, no. 16: 3571. https://doi.org/10.3390/molecules25163571

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