Aptamers in Non-Small Cell Lung Cancer Treatment
Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-090 Lublin, Poland
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Molecules 2020, 25(14), 3138; https://doi.org/10.3390/molecules25143138
Received: 5 June 2020
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Revised: 16 June 2020
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Accepted: 8 July 2020
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Published: 9 July 2020
Aptamers are short, single-stranded oligonucleotides which are capable of specifically binding to single molecules and cellular structures. Aptamers are also known as “chemical antibodies”. Compared to monoclonal antibodies, they are characterized by higher reaction specificity, lower molecular weight, lower production costs, and lower variability in the production stage. Aptamer research has been extended during the past twenty years, but only Macugen® has been accepted by the Food and Drug Administration (FDA) to date, and few aptamers have been examined in clinical trials. In vitro studies with aptamers have shown that they may take part in the regulation of cancer progression, angiogenesis, and metastasis processes. In this article, we focus on the potential use of aptamers in non-small cell lung cancer treatment.
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MDPI and ACS Style
Wieleba, I.; Wojas-Krawczyk, K.; Krawczyk, P. Aptamers in Non-Small Cell Lung Cancer Treatment. Molecules 2020, 25, 3138. https://doi.org/10.3390/molecules25143138
AMA Style
Wieleba I, Wojas-Krawczyk K, Krawczyk P. Aptamers in Non-Small Cell Lung Cancer Treatment. Molecules. 2020; 25(14):3138. https://doi.org/10.3390/molecules25143138
Chicago/Turabian StyleWieleba, Irena, Kamila Wojas-Krawczyk, and Paweł Krawczyk. 2020. "Aptamers in Non-Small Cell Lung Cancer Treatment" Molecules 25, no. 14: 3138. https://doi.org/10.3390/molecules25143138
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