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Open AccessReview

Quinoxaline Derivatives as Antiviral Agents: A Systematic Review

Laboratoire de Pharmaco-Chimie Radicalaire, Institut de Chimie Radicalaire ICR, Aix Marseille Univ, CNRS, UMR 7273, 13005 Marseille, France
Oncopharma, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille (AP-HM), 13005 Marseille, France
Service central de la qualité et de l’information pharmaceutiques (SCQIP), Assistance Publique-Hôpitaux de Marseille (AP-HM), 13005 Marseille, France
Author to whom correspondence should be addressed.
Molecules 2020, 25(12), 2784;
Received: 26 May 2020 / Revised: 4 June 2020 / Accepted: 9 June 2020 / Published: 16 June 2020
(This article belongs to the Section Medicinal Chemistry)
Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties (antiviral, anticancer, and antileishmanial), ensuring them a bright future in medicinal chemistry. Objectives: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives. Methods: Study compiles and discusses recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives, covering the literature between 2010 and 2020. Results: A final total of 20 studies included in this review. Conclusions: This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold. View Full-Text
Keywords: quinoxaline; antiviral; SAR; biological applications; chemistry quinoxaline; antiviral; SAR; biological applications; chemistry
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MDPI and ACS Style

Montana, M.; Montero, V.; Khoumeri, O.; Vanelle, P. Quinoxaline Derivatives as Antiviral Agents: A Systematic Review. Molecules 2020, 25, 2784.

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