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Article

Size and Shape-Dependent Antimicrobial Activities of Silver and Gold Nanoparticles: A Model Study as Potential Fungicides

1
Sensors Mechanisms Research and Technology Center (The SMART Center), Chemistry and Environmental Science Department, New Jersey Institute of Technology, University Heights, 161 Warren Street, Newark, NJ 07102, USA
2
Department of Sustainable Bioproducts, College of Forest Resources, Mississippi State University, Starkville, MS 39759, USA
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Department of Chemistry, Center for Research in Advanced Sensing Technologies & Environmental Sustainability (CREATES), State University of New York at Binghamton, P.O. Box 6000 Binghamton, NY 13902, USA
4
Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS 39759, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Adeyemi S. Adeleye and Yuxiong Huang
Molecules 2020, 25(11), 2682; https://doi.org/10.3390/molecules25112682
Received: 30 April 2020 / Revised: 31 May 2020 / Accepted: 3 June 2020 / Published: 9 June 2020
Plant-based pathogenic microbes hinder the yield and quality of food production. Plant diseases have caused an increase in food costs due to crop destruction. There is a need to develop novel methods that can target and mitigate pathogenic microbes. This study focuses on investigating the effects of luteolin tetraphosphate derived silver nanoparticles (LTP-AgNPs) and gold nanoparticles (LTP-AuNPs) as a therapeutic agent on the growth and expression of plant-based bacteria and fungi. In this study, the silver and gold nanoparticles were synthesized at room temperature using luteolin tetraphosphate (LTP) as the reducing and capping agents. The synthesis of LTP-AgNPs and LTP-AuNP was characterized by Transmission Electron Microscopy (TEM) and size distribution. The TEM images of both LTP-AgNPs and LTP-AuNPs showed different sizes and shapes (spherical, quasi-spherical, and cuboidal). The antimicrobial test was conducted using fungi: Aspergillus nidulans, Trichaptum biforme, Penicillium italicum, Fusarium oxysporum, and Colletotrichum gloeosporioides, while the class of bacteria employed include Pseudomonas aeruginosa, Aeromonas hydrophila, Escherichia coli, and Citrobacter freundii as Gram (−) bacteria, and Listeria monocytogenes and Staphylococcus epidermidis as Gram (+) bacterium. The antifungal study demonstrated the selective size and shape-dependent capabilities in which smaller sized spherical (9 nm) and quasi-spherical (21 nm) AgNPs exhibited 100% inhibition of the tested fungi and bacteria. The LTP-AgNPs exhibited a higher antimicrobial activity than LTP-AuNPs. We have demonstrated that smaller sized AgNPs showed excellent inhibition of A. nidulans growth compared to the larger size nanoparticles. These results suggest that LTP-AuNP and LTP-AgNPs could be used to address the detection and remediation of pathogenic fungi, respectively. View Full-Text
Keywords: luteolin; silver nanoparticles; luteolin tetraphosphate; gold nanoparticles; antimicrobial; remediation; fungicide; fungi luteolin; silver nanoparticles; luteolin tetraphosphate; gold nanoparticles; antimicrobial; remediation; fungicide; fungi
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MDPI and ACS Style

Osonga, F.J.; Akgul, A.; Yazgan, I.; Akgul, A.; Eshun, G.B.; Sakhaee, L.; Sadik, O.A. Size and Shape-Dependent Antimicrobial Activities of Silver and Gold Nanoparticles: A Model Study as Potential Fungicides. Molecules 2020, 25, 2682. https://doi.org/10.3390/molecules25112682

AMA Style

Osonga FJ, Akgul A, Yazgan I, Akgul A, Eshun GB, Sakhaee L, Sadik OA. Size and Shape-Dependent Antimicrobial Activities of Silver and Gold Nanoparticles: A Model Study as Potential Fungicides. Molecules. 2020; 25(11):2682. https://doi.org/10.3390/molecules25112682

Chicago/Turabian Style

Osonga, Francis J., Ali Akgul, Idris Yazgan, Ayfer Akgul, Gaddi B. Eshun, Laura Sakhaee, and Omowunmi A. Sadik. 2020. "Size and Shape-Dependent Antimicrobial Activities of Silver and Gold Nanoparticles: A Model Study as Potential Fungicides" Molecules 25, no. 11: 2682. https://doi.org/10.3390/molecules25112682

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