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Article

Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels

1
Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil
2
PhD student Graduate Program in Physiological Sciences, Higher Institute of Biomedical Sciences State University of Ceará–UECE, Fortaleza 60714-903, CE, Brazil
3
PhD student in Biotechnology by the Northeastern Biotechnology Network - RENORBIO, State University of Ceará-UECE, Fortaleza 60714-903, CE, Brazil
4
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Karel Šmejkal
Molecules 2020, 25(11), 2681; https://doi.org/10.3390/molecules25112681
Received: 29 April 2020 / Revised: 29 May 2020 / Accepted: 1 June 2020 / Published: 9 June 2020
(This article belongs to the Special Issue Bioactive Natural Compounds and Their Mechanisms of Action)
Carveol is a monoterpene present in the structure of many plant products. It has a variety of biological activities: antioxidant, anticancer and vasorelaxation. However, studies investigating the effect of monoterpenoids on human vessels have not yet been described. Thus, the present study aimed to characterize the effect of (−)-carveol on human umbilical arteries (HUAs). HUA ring preparations were isolated and subjected to isometric tension recordings of umbilical artery smooth muscle contractions. (−)-Carveol exhibited a significant vasorelaxant effect on KCl and 5-HT-induced contractions, obtaining EC50 values of 344.25 ± 8.4 and 175.82 ± 4.05 µM, respectively. The participation of calcium channels in the relaxation produced by (−)-carveol was analyzed using vessels pre-incubated with (−)-carveol (2000 µM) in a calcium-free medium, where the induction of contractions was abolished. The vasorelaxant effect of (−)-carveol on HUAs was reduced by tetraethylammonium (TEA), which increased the (−)-carveol EC50 to 484.87 ± 6.55 µM. The present study revealed that (−)-carveol possesses a vasorelaxant activity in HUAs, which was dependent on the opening of calcium and potassium channels. These results pave the way for further studies involving the use of monoterpenoids for the vasodilatation of HUAs. These molecules have the potential to treat diseases such as pre-eclampsia, which is characterized by resistance in umbilical arteries. View Full-Text
Keywords: carveol; human umbilical artery; vasorelaxant carveol; human umbilical artery; vasorelaxant
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MDPI and ACS Style

Evaristo Rodrigues da Silva, R.; de Alencar Silva, A.; Pereira-de-Morais, L.; de Sousa Almeida, N.; Iriti, M.; Kerntopf, M.R.; Menezes, I.R.A.d.; Coutinho, H.D.M.; Barbosa, R. Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels. Molecules 2020, 25, 2681. https://doi.org/10.3390/molecules25112681

AMA Style

Evaristo Rodrigues da Silva R, de Alencar Silva A, Pereira-de-Morais L, de Sousa Almeida N, Iriti M, Kerntopf MR, Menezes IRAd, Coutinho HDM, Barbosa R. Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels. Molecules. 2020; 25(11):2681. https://doi.org/10.3390/molecules25112681

Chicago/Turabian Style

Evaristo Rodrigues da Silva, Renata, Andressa de Alencar Silva, Luís Pereira-de-Morais, Nayane de Sousa Almeida, Marcello Iriti, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, and Roseli Barbosa. 2020. "Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels" Molecules 25, no. 11: 2681. https://doi.org/10.3390/molecules25112681

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