Next Article in Journal
Neobavaisoflavone Inhibits Melanogenesis through the Regulation of Akt/GSK-3β and MEK/ERK Pathways in B16F10 Cells and a Reconstructed Human 3D Skin Model
Next Article in Special Issue
The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies
Previous Article in Journal
Rutamarin: Efficient Liquid–Liquid Chromatographic Isolation from Ruta graveolens L. and Evaluation of Its In Vitro and In Silico MAO-B Inhibitory Activity
Previous Article in Special Issue
Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2)

Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels

Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil
PhD student Graduate Program in Physiological Sciences, Higher Institute of Biomedical Sciences State University of Ceará–UECE, Fortaleza 60714-903, CE, Brazil
PhD student in Biotechnology by the Northeastern Biotechnology Network - RENORBIO, State University of Ceará-UECE, Fortaleza 60714-903, CE, Brazil
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy
Author to whom correspondence should be addressed.
Academic Editor: Karel Šmejkal
Molecules 2020, 25(11), 2681;
Received: 29 April 2020 / Revised: 29 May 2020 / Accepted: 1 June 2020 / Published: 9 June 2020
(This article belongs to the Special Issue Bioactive Natural Compounds and Their Mechanisms of Action)
Carveol is a monoterpene present in the structure of many plant products. It has a variety of biological activities: antioxidant, anticancer and vasorelaxation. However, studies investigating the effect of monoterpenoids on human vessels have not yet been described. Thus, the present study aimed to characterize the effect of (−)-carveol on human umbilical arteries (HUAs). HUA ring preparations were isolated and subjected to isometric tension recordings of umbilical artery smooth muscle contractions. (−)-Carveol exhibited a significant vasorelaxant effect on KCl and 5-HT-induced contractions, obtaining EC50 values of 344.25 ± 8.4 and 175.82 ± 4.05 µM, respectively. The participation of calcium channels in the relaxation produced by (−)-carveol was analyzed using vessels pre-incubated with (−)-carveol (2000 µM) in a calcium-free medium, where the induction of contractions was abolished. The vasorelaxant effect of (−)-carveol on HUAs was reduced by tetraethylammonium (TEA), which increased the (−)-carveol EC50 to 484.87 ± 6.55 µM. The present study revealed that (−)-carveol possesses a vasorelaxant activity in HUAs, which was dependent on the opening of calcium and potassium channels. These results pave the way for further studies involving the use of monoterpenoids for the vasodilatation of HUAs. These molecules have the potential to treat diseases such as pre-eclampsia, which is characterized by resistance in umbilical arteries. View Full-Text
Keywords: carveol; human umbilical artery; vasorelaxant carveol; human umbilical artery; vasorelaxant
Show Figures

Figure 1

MDPI and ACS Style

Evaristo Rodrigues da Silva, R.; de Alencar Silva, A.; Pereira-de-Morais, L.; de Sousa Almeida, N.; Iriti, M.; Kerntopf, M.R.; Menezes, I.R.A.d.; Coutinho, H.D.M.; Barbosa, R. Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels. Molecules 2020, 25, 2681.

AMA Style

Evaristo Rodrigues da Silva R, de Alencar Silva A, Pereira-de-Morais L, de Sousa Almeida N, Iriti M, Kerntopf MR, Menezes IRAd, Coutinho HDM, Barbosa R. Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels. Molecules. 2020; 25(11):2681.

Chicago/Turabian Style

Evaristo Rodrigues da Silva, Renata, Andressa de Alencar Silva, Luís Pereira-de-Morais, Nayane de Sousa Almeida, Marcello Iriti, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, and Roseli Barbosa. 2020. "Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels" Molecules 25, no. 11: 2681.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop