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Article

Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles

1
Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA
2
Center for Molecular Engineering and Materials Science Division, Argonne National Laboratory, Lemont, IL 60439, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Jens Smiatek
Molecules 2020, 25(11), 2553; https://doi.org/10.3390/molecules25112553
Received: 8 May 2020 / Revised: 26 May 2020 / Accepted: 27 May 2020 / Published: 30 May 2020
(This article belongs to the Special Issue The Progresses on Polyelectrolytes and Polyelectrolyte Complexes)
A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized a well-defined diblock polyelectrolyte system, poly(2-methacryloyloxyethyl phosphorylcholine methacrylate)-block-poly((vinylbenzyl) trimethylammonium) (PMPC-PVBTMA), at various neutral and charged block lengths to compare directly against PCM structure–property relationships centered on poly(ethylene glycol)-block-poly((vinylbenzyl) trimethylammonium) (PEG-PVBTMA) and poly(ethylene glycol)-block-poly(l-lysine) (PEG-PLK). After complexation with a common polyanion, poly(sodium acrylate), the resulting PCMs were characterized by dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). We observed uniform assemblies of spherical micelles with a diameter ~1.5–2× larger when PMPC-PVBTMA was used compared to PEG-PLK and PEG-PVBTMA via SAXS and DLS. In addition, PEG-PLK PCMs proved most resistant to dissolution by both monovalent and divalent salt, followed by PEG-PVBTMA then PMPC-PVBTMA. All micelle systems were serum stable in 100% fetal bovine serum over the course of 8 h by time-resolved DLS, demonstrating minimal interactions with serum proteins and potential as in vivo drug delivery vehicles. This thorough study of the synthesis, assembly, and characterization of zwitterionic polymers in PCMs advances the design space for charge-driven micelle assemblies. View Full-Text
Keywords: polyelectrolyte complexes; micelles; zwitterions; PEG; polymer chemistry polyelectrolyte complexes; micelles; zwitterions; PEG; polymer chemistry
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MDPI and ACS Style

Ting, J.M.; Marras, A.E.; Mitchell, J.D.; Campagna, T.R.; Tirrell, M.V. Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles. Molecules 2020, 25, 2553. https://doi.org/10.3390/molecules25112553

AMA Style

Ting JM, Marras AE, Mitchell JD, Campagna TR, Tirrell MV. Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles. Molecules. 2020; 25(11):2553. https://doi.org/10.3390/molecules25112553

Chicago/Turabian Style

Ting, Jeffrey M., Alexander E. Marras, Joseph D. Mitchell, Trinity R. Campagna, and Matthew V. Tirrell 2020. "Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles" Molecules 25, no. 11: 2553. https://doi.org/10.3390/molecules25112553

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