Next Article in Journal
Sexual Dimorphism in Energy Metabolism of Wistar Rats Using Data Analysis
Previous Article in Journal
Bacillus amyloliquefaciens RWL-1 as a New Potential Strain for Augmenting Biochemical and Nutritional Composition of Fermented Soybean

This is an early access version, the complete PDF, HTML, and XML versions will be available soon.

Open AccessReview

Mechanisms Regulating the UPS-ALS Crosstalk: The Role of Proteaphagy

ITAV-CNRS USR 3505 IPBS-UPS, 1 place Pierre Potier, 31106 Toulouse, France
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(10), 2352; https://doi.org/10.3390/molecules25102352
Received: 26 April 2020 / Revised: 14 May 2020 / Accepted: 16 May 2020 / Published: 18 May 2020
Protein degradation is tightly regulated inside cells because of its utmost importance for protein homeostasis (proteostasis). The two major intracellular proteolytic pathways are the ubiquitin-proteasome and the autophagy-lysosome systems which ensure the fate of proteins when modified by various members of the ubiquitin family. These pathways are tightly interconnected by receptors and cofactors that recognize distinct chain architectures to connect with either the proteasome or autophagy under distinct physiologic and pathologic situations. The degradation of proteasome by autophagy, known as proteaphagy, plays an important role in this crosstalk since it favours the activity of autophagy in the absence of fully active proteasomes. Recently described in several biological models, proteaphagy appears to help the cell to survive when proteostasis is broken by the absence of nutrients or the excess of proteins accumulated under various stress conditions. Emerging evidence indicates that proteaphagy could be permanently activated in some types of cancer or when chemoresistance is observed in patients.
Keywords: ubiquitin proteasome system; autophagy; ubiquitin-like; proteaphagy; pathology ubiquitin proteasome system; autophagy; ubiquitin-like; proteaphagy; pathology
Show Figures

Graphical abstract

MDPI and ACS Style

Quinet, G.; Gonzalez-Santamarta, M.; Louche, C.; Rodriguez, M.S. Mechanisms Regulating the UPS-ALS Crosstalk: The Role of Proteaphagy. Molecules 2020, 25, 2352.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop