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Molecules
Volume 25
Issue 10
10.3390/molecules25102306
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Article

Trichothecin Inhibits Cancer-Related Features in Colorectal Cancer Development by Targeting STAT3

by
Xin Qi
1,
Meng Li
1,
Xiao-min Zhang
1,
Xiu-fen Dai
1,
Jian Cui
1,
De-hai Li
1,2,3,
Qian-qun Gu
1,3,
Zhi-hua Lv
1,3,* and
Jing Li
1,2,3,*
1
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China
3
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(10), 2306; https://doi.org/10.3390/molecules25102306
Received: 21 February 2020 / Revised: 30 April 2020 / Accepted: 5 May 2020 / Published: 14 May 2020
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Abstract

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that contributes to cancer progression through multiple processes of cancer development, which makes it an attractive target for cancer therapy. The IL-6/STAT3 pathway is associated with an advanced stage in colorectal cancer patients. In this study, we identified trichothecin (TCN) as a novel STAT3 inhibitor. TCN was found to bind to the SH2 domain of STAT3 and inhibit STAT3 activation and dimerization, thereby blocking STAT3 nuclear translocation and transcriptional activity. TCN did not affect phosphorylation levels of STAT1. TCN significantly inhibited cell growth, arrested cell cycle at the G0/G1 phase, and induced apoptosis in HCT 116 cells. In addition, the capacities of colony formation, migration, and invasion of HCT 116 cells were impaired upon exposure to TCN with or without IL-6 stimulation. In addition, TCN treatment abolished the tube formation of HUVEC cells in vitro. Taken together, these results highlight that TCN inhibits various cancer-related features in colorectal cancer development in vitro by targeting STAT3, indicating that TCN is a promising STAT3 inhibitor that deserves further exploration in the future. View Full-Text
Keywords: cancer; trichothecin; STAT3; inhibitor; HCT 116 cancer; trichothecin; STAT3; inhibitor; HCT 116
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MDPI and ACS Style

Qi, X.; Li, M.; Zhang, X.-m.; Dai, X.-f.; Cui, J.; Li, D.-h.; Gu, Q.-q.; Lv, Z.-h.; Li, J. Trichothecin Inhibits Cancer-Related Features in Colorectal Cancer Development by Targeting STAT3. Molecules 2020, 25, 2306. https://doi.org/10.3390/molecules25102306

AMA Style

Qi X, Li M, Zhang X-m, Dai X-f, Cui J, Li D-h, Gu Q-q, Lv Z-h, Li J. Trichothecin Inhibits Cancer-Related Features in Colorectal Cancer Development by Targeting STAT3. Molecules. 2020; 25(10):2306. https://doi.org/10.3390/molecules25102306

Chicago/Turabian Style

Qi, Xin, Meng Li, Xiao-min Zhang, Xiu-fen Dai, Jian Cui, De-hai Li, Qian-qun Gu, Zhi-hua Lv, and Jing Li. 2020. "Trichothecin Inhibits Cancer-Related Features in Colorectal Cancer Development by Targeting STAT3" Molecules 25, no. 10: 2306. https://doi.org/10.3390/molecules25102306

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