Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications
by
Dimitrios Giliopoulos 1,*, Alexandra Zamboulis 2, 
Dimitrios Giannakoudakis 1
, 
Dimitrios Bikiaris 2,* and Konstantinos Triantafyllidis 1,*
Dimitrios Giliopoulos 1,*, Alexandra Zamboulis 2, Dimitrios Giannakoudakis 1, Dimitrios Bikiaris 2,* and Konstantinos Triantafyllidis 1,*
1
Laboratory of Chemical and Environmental Technology, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
2
Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
*
Authors to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Molecules 2020, 25(1), 185; https://doi.org/10.3390/molecules25010185
Received: 18 November 2019 / Revised: 23 December 2019 / Accepted: 28 December 2019 / Published: 1 January 2020
(This article belongs to the Special Issue Metal Organic Frameworks: Synthesis and Application)
The utilization of polymer/metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied due to their unique properties that arise from MOFs or hybrid composite systems. This review focuses on the types of polymer/MOF nanocomposites used in drug delivery and imaging applications. Initially, a comprehensive introduction to the synthesis and structure of MOFs and bio-MOFs is presented. Subsequently, the properties and the performance of polymer/MOF nanocomposites used in these applications are examined, in relation to the approach applied for their synthesis: (i) non-covalent attachment, (ii) covalent attachment, (iii) polymer coordination to metal ions, (iv) MOF encapsulation in polymers, and (v) other strategies. A critical comparison and discussion of the effectiveness of polymer/MOF nanocomposites regarding their synthesis methods and their structural characteristics is presented.
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Keywords:
metal organic framework; polymer nanocomposites; drug delivery; magnetic resonance imaging
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MDPI and ACS Style
Giliopoulos, D.; Zamboulis, A.; Giannakoudakis, D.; Bikiaris, D.; Triantafyllidis, K. Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications. Molecules 2020, 25, 185.
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