Next Article in Journal
In Situ Production and Application of Cellulose Nanofibers to Improve Recycled Paper Production
Next Article in Special Issue
Synthesis of (1,2,3-triazol-4-yl)methyl Phosphinates and (1,2,3-Triazol-4-yl)methyl Phosphates by Copper-Catalyzed Azide-Alkyne Cycloaddition
Previous Article in Journal
Effects of Different Biochars on Wheat Growth Parameters, Yield and Soil Fertility Status in a Silty Clay Loam Soil
Previous Article in Special Issue
Novel 6a,12b-Dihydro-6H,7H-chromeno[3,4-c] chromen-6-ones: Synthesis, Structure and Antifungal Activity
Open AccessArticle

Synthesis of Terpyridines: Simple Reactions—What Could Possibly Go Wrong?

University of Basel, Department of Chemistry, BPR 1096, Mattenstrasse 24a, CH-4058 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Gianfranco Favi
Molecules 2019, 24(9), 1799; https://doi.org/10.3390/molecules24091799
Received: 15 April 2019 / Revised: 7 May 2019 / Accepted: 8 May 2019 / Published: 9 May 2019
(This article belongs to the Special Issue Modern Strategies for Heterocycle Synthesis)
The preparation of 24-functionalized 12,22:26,32-terpyridines (4′-functionalized 3,2:6′,3″-terpyridines) by the reaction of three 4-alkoxybenzaldehydes with 3-acetylpyridine and ammonia was investigated; under identical reaction conditions, two (R =nC4H9, C2H5) gave the expected products whereas a third (R = nC3H7) gave only a cyclohexanol derivative derived from the condensation of three molecules of 3-acetylpyridine with two of 4-(n-propoxy)benzaldehyde. A comprehensive survey of “unexpected” products from reactions of ArCOCH3 derivatives with aromatic aldehydes is presented. Three different types of alternative product are identified. View Full-Text
Keywords: terpyridines; 3,2′:6′,3″-terpyridine; cyclohexanol derivative; condensation; heterocyclic terpyridines; 3,2′:6′,3″-terpyridine; cyclohexanol derivative; condensation; heterocyclic
Show Figures

Figure 1

MDPI and ACS Style

Rocco, D.; Housecroft, C.E.; Constable, E.C. Synthesis of Terpyridines: Simple Reactions—What Could Possibly Go Wrong? Molecules 2019, 24, 1799.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop