Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors
AbstractThe pyrimidine nucleus is a versatile core in the development of antiretroviral agents. On this basis, a series of pyrimidine-2,4-diones linked to an isoxazolidine nucleus have been synthesized and tested as nucleoside analogs, endowed with potential anti-HIV (human immunodeficiency virus) activity. Compounds 6a–c, characterized by the presence of an ethereal group at C-3, show HIV reverse transcriptase (RT) inhibitor activity in the nanomolar range as well as HIV-infection inhibitor activity in the low micromolar with no toxicity. In the same context, compound 7b shows only a negligible inhibition of RT HIV. View Full-Text
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Romeo, R.; Iannazzo, D.; Veltri, L.; Gabriele, B.; Macchi, B.; Frezza, C.; Marino-Merlo, F.; Giofrè, S.V. Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors. Molecules 2019, 24, 1718.
Romeo R, Iannazzo D, Veltri L, Gabriele B, Macchi B, Frezza C, Marino-Merlo F, Giofrè SV. Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors. Molecules. 2019; 24(9):1718.Chicago/Turabian Style
Romeo, Roberto; Iannazzo, Daniela; Veltri, Lucia; Gabriele, Bartolo; Macchi, Beatrice; Frezza, Caterina; Marino-Merlo, Francesca; Giofrè, Salvatore V. 2019. "Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors." Molecules 24, no. 9: 1718.
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