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Effects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics

1
Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China
2
School of Pharmaceutical Sciences, Jilin University, Fujin Road 1266, Changchun 130021, China
3
College of Chinese Medicinal Materials, Jilin Agriculture University, Xincheng Street 2888, Changchun 130118, China
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(9), 1712; https://doi.org/10.3390/molecules24091712
Received: 9 March 2019 / Revised: 26 April 2019 / Accepted: 1 May 2019 / Published: 2 May 2019
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Abstract

Major depressive disorder (MDD), also known as depression, is a state characterized by low mood and aversion to activity. Platycodins Folium (PF) is the dried leaf of Platycodon grandiflorum, with anti-inflammatory and antioxidative activities. Our previous research suggested that PF was rich in flavonoids, phenols, organic acids, triterpenoid saponins, coumarins and terpenoids. This study aimed to investigate the antidepressant effect of PF using lipopolysaccharide (LPS)-induced depressive mice. Several behavior tests (sucrose preference test (SPT), forced swimming test (FST) and tail suspension test (TST)) and biochemical parameters (IL-6, TNF-α and SOD levels) were used to evaluate the antidepressive effect of PF on LPS-induced depression model. Furthermore, a UPLC-Q/TOF-MS-based metabolomics approach was applied to explore the latent mechanism of PF in attenuating depression. As a result, a total of 21 and 11 metabolites that potentially contribute to MDD progress and PF treatment were identified in serum and hippocampus, respectively. The analysis of metabolic pathways revealed that lipid metabolism, amino acid metabolism, energy metabolism, arachidonic acid metabolism, glutathione metabolism and inositol phosphate metabolism were disturbed in a model of mice undergoing MDD and PF treatment. These results help us to understand the pathogenesis of depression in depth, and to discover targets for clinical diagnosis and treatment. They also provide the possibility of developing PF into an anti-depressantive agent. View Full-Text
Keywords: Platycodins Folium; LPS-induced depression; metabolomics; UPLC-Q/TOF-MS Platycodins Folium; LPS-induced depression; metabolomics; UPLC-Q/TOF-MS
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Wang, C.; Lin, H.; Yang, N.; Wang, H.; Zhao, Y.; Li, P.; Liu, J.; Wang, F. Effects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics. Molecules 2019, 24, 1712.

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