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Open AccessArticle

Small AntiMicrobial Peptide with In Vivo Activity Against Sepsis

Sorbonne Université, École Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM, 75005 Paris, France
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Academic Editors: Henry Mosberg, Tomi Sawyer and Carrie Haskell-Luevano
Molecules 2019, 24(9), 1702; https://doi.org/10.3390/molecules24091702
Received: 30 March 2019 / Revised: 15 April 2019 / Accepted: 17 April 2019 / Published: 1 May 2019
Antimicrobial peptides (AMPs) are considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and alternative mechanisms of action compared to conventional antibiotics. Although AMPs present considerable advantages over conventional antibiotics, their clinical and commercial development still have some limitations, because of their potential toxicity, susceptibility to proteases, and high cost of production. To overcome these drawbacks, the use of peptides mimics is anticipated to avoid the proteolysis, while the identification of minimalist peptide sequences retaining antimicrobial activities could bring a solution for the cost issue. We describe here new polycationic -amino acids combining these two properties, that we used to design small dipeptides that appeared to be active against Gram-positive and Gram-negative bacteria, selective against prokaryotic versus mammalian cells, and highly stable in human plasma. Moreover, the in vivo data activity obtained in septic mice reveals that the bacterial killing effect allows the control of the infection and increases the survival rate of cecal ligature and puncture (CLP)-treated mice. View Full-Text
Keywords: polycationic -amino acids; small antimicrobial peptides; sepsis polycationic -amino acids; small antimicrobial peptides; sepsis
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MDPI and ACS Style

Boullet, H.; Bentot, F.; Hequet, A.; Ganem-Elbaz, C.; Bechara, C.; Pacreau, E.; Launay, P.; Sagan, S.; Jolivalt, C.; Lacombe, C.; Moumné, R.; Karoyan, P. Small AntiMicrobial Peptide with In Vivo Activity Against Sepsis. Molecules 2019, 24, 1702. https://doi.org/10.3390/molecules24091702

AMA Style

Boullet H, Bentot F, Hequet A, Ganem-Elbaz C, Bechara C, Pacreau E, Launay P, Sagan S, Jolivalt C, Lacombe C, Moumné R, Karoyan P. Small AntiMicrobial Peptide with In Vivo Activity Against Sepsis. Molecules. 2019; 24(9):1702. https://doi.org/10.3390/molecules24091702

Chicago/Turabian Style

Boullet, Héloise; Bentot, Fayçal; Hequet, Arnaud; Ganem-Elbaz, Carine; Bechara, Chérine; Pacreau, Emeline; Launay, Pierre; Sagan, Sandrine; Jolivalt, Claude; Lacombe, Claire; Moumné, Roba; Karoyan, Philippe. 2019. "Small AntiMicrobial Peptide with In Vivo Activity Against Sepsis" Molecules 24, no. 9: 1702. https://doi.org/10.3390/molecules24091702

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