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Article

Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus

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College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
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Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
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Jiyang College of Zhejiang Agriculture and Forestry University, Zhu’ji 311800, China
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Zhejiang Chinese Medical University, Zhejiang, Hangzhou 310053, China
*
Author to whom correspondence should be addressed.
Academic Editors: Raffaele Capasso and Lorenzo Di Cesare Mannelli
Molecules 2019, 24(8), 1454; https://doi.org/10.3390/molecules24081454
Received: 28 February 2019 / Revised: 27 March 2019 / Accepted: 4 April 2019 / Published: 12 April 2019
(This article belongs to the Special Issue Plant Extracts: Biological and Pharmacological Activity)
Rheum palmatum L. is a traditional Chinese medicine with various pharmacological properties, including anti-inflammatory, antibacterial, and detoxification effects. In this study, the mechanism of the hypoglycemic effect of purified anthraquinone-Glycoside from Rheum palmatum L. (PAGR) in streptozotocin (STZ) and high-fat diet induced type 2 diabetes mellitus (T2DM) in rats was investigated. The rats were randomly divided into normal (NC), T2DM, metformin (Met), low, middle (Mid), and high (Hig) does of PAGR groups. After six weeks of continuous administration of PAGR, the serum indices and tissue protein expression were determined, and the pathological changes in liver, kidney, and pancreas tissues were observed. The results showed that compared with the type 2 diabetes mellitus group, the fasting blood glucose (FBG), total cholesterol (TC), and triglyceride (TG) levels in the serum of rats in the PAGR treatment groups were significantly decreased, while superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) levels were noticeably increased. The expression of Fas ligand (FasL), cytochrome C (Cyt-c), and caspase-3 in pancreatic tissue was obviously decreased, and the pathological damage to the liver, kidney, and pancreas was improved. These indicate that PAGR can reduce oxidative stress in rats with diabetes mellitus by improving blood lipid metabolism and enhancing their antioxidant capacity, thereby regulating the mitochondrial apoptotic pathway to inhibitβ-cell apoptosis and improve β-cell function. Furthermore, it can regulate Fas/FasL-mediated apoptosis signaling pathway to inhibit β-cell apoptosis, thereby lowering blood glucose levels and improving T2DM. View Full-Text
Keywords: Rheum palmatum L.; type 2 diabetes mellitus; oxidative stress; apoptosis Rheum palmatum L.; type 2 diabetes mellitus; oxidative stress; apoptosis
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MDPI and ACS Style

Cheng, F.-R.; Cui, H.-X.; Fang, J.-L.; Yuan, K.; Guo, Y. Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus. Molecules 2019, 24, 1454. https://doi.org/10.3390/molecules24081454

AMA Style

Cheng F-R, Cui H-X, Fang J-L, Yuan K, Guo Y. Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus. Molecules. 2019; 24(8):1454. https://doi.org/10.3390/molecules24081454

Chicago/Turabian Style

Cheng, Fang-Rong, Hong-Xin Cui, Ji-Li Fang, Ke Yuan, and Ying Guo. 2019. "Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation from Rheum Palmatum L. on Type 2 Diabetes Mellitus" Molecules 24, no. 8: 1454. https://doi.org/10.3390/molecules24081454

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