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Open AccessArticle

Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.)

Department of Pharmacognosy, Faculty of Pharmacy, Medical University–Sofia, 2 Dunav str., 1000 Sofia, Bulgaria
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA
Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 61242 Brno, Czech Republic
Department of Food Science, Czech University of Life Sciences Prague, Kamycka 129, 165 00 Prague 6–Suchdol, Czech Republic
Institute of Experimental Botany, Czech Academy of Sciences, Rozvojová 263, 16502 Prague, Czech Republic
Authors to whom correspondence should be addressed.
Academic Editor: Francesco Epifano
Molecules 2019, 24(7), 1419;
Received: 28 March 2019 / Revised: 5 April 2019 / Accepted: 6 April 2019 / Published: 11 April 2019
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
Astragalus is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g., immunomodulating, antibacterial, antiviral and hepatoprotective. This inspired us to analyze the Bulgarian endemic A. aitosensis (Ivanisch.) to obtain deeper information about its phenolic components. We used extensive chromatographic separation of A. aitosensis extract to obtain seven phenolic compounds (17), which were identified using combined LC-MS and NMR spectral studies. The 1D and 2D NMR analyses and HR-MS allowed us to resolve the structures of known compounds 57 as isorhamnetin-3-O-robinobioside, isorhamnetin-3-O-(2,6-di-O-α-rhamno-pyranosyl-β-galactopyranoside), and alangiflavoside, respectively, and further comparison of these spectral data with available literature helped us with structural analysis of newly described flavonoid glycosides 14. These were described in plant source for the first time. View Full-Text
Keywords: Astragalus aitosensis; flavonoid; glycoside Astragalus aitosensis; flavonoid; glycoside
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MDPI and ACS Style

Vasilev, H.; Ross, S.; Šmejkal, K.; Maršík, P.; Jankovská, D.; Havlík, J.; Veselý, O. Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.). Molecules 2019, 24, 1419.

AMA Style

Vasilev H, Ross S, Šmejkal K, Maršík P, Jankovská D, Havlík J, Veselý O. Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.). Molecules. 2019; 24(7):1419.

Chicago/Turabian Style

Vasilev, Hristo; Ross, Samir; Šmejkal, Karel; Maršík, Petr; Jankovská, Dagmar; Havlík, Jaroslav; Veselý, Ondřej. 2019. "Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.)" Molecules 24, no. 7: 1419.

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