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New Dammarane-Type Saponins from Gynostemma pentaphyllum

1
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
2
Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan
3
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
4
Department of Research and Development, Starsci Biotech Co. Ltd., Taipei 112, Taiwan
5
The Ph.D. Program in Clinical Drug Development of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
6
Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
7
Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan
8
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Francesco Epifano
Molecules 2019, 24(7), 1375; https://doi.org/10.3390/molecules24071375
Received: 23 February 2019 / Revised: 27 March 2019 / Accepted: 5 April 2019 / Published: 8 April 2019
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
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Abstract

Six new dammarane-type saponins, gypenosides CP1-6 (16), along with 19 known compounds 725, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2). View Full-Text
Keywords: Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, P.-Y.; Chang, C.-C.; Huang, H.-C.; Zhang, L.-J.; Liaw, C.-C.; Lin, Y.-C.; Nguyen, N.-L.; Vo, T.-H.; Cheng, Y.-Y.; Morris-Natschke, S.L.; Lee, K.-H.; Kuo, Y.-H. New Dammarane-Type Saponins from Gynostemma pentaphyllum. Molecules 2019, 24, 1375.

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