Next Article in Journal
KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways
Next Article in Special Issue
Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.)
Previous Article in Journal
Perilla frutescens Britton: A Comprehensive Study on Flavor/Taste and Chemical Properties During the Roasting Process
Previous Article in Special Issue
Allamanda cathartica: A Review of the Phytochemistry, Pharmacology, Toxicology, and Biotechnology
Article Menu
Issue 7 (April-1) cover image

Export Article

Open AccessArticle

New Dammarane-Type Saponins from Gynostemma pentaphyllum

Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Department of Research and Development, Starsci Biotech Co. Ltd., Taipei 112, Taiwan
The Ph.D. Program in Clinical Drug Development of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Francesco Epifano
Molecules 2019, 24(7), 1375;
Received: 23 February 2019 / Revised: 27 March 2019 / Accepted: 5 April 2019 / Published: 8 April 2019
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
PDF [809 KB, uploaded 12 April 2019]


Six new dammarane-type saponins, gypenosides CP1-6 (16), along with 19 known compounds 725, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2). View Full-Text
Keywords: Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Chen, P.-Y.; Chang, C.-C.; Huang, H.-C.; Zhang, L.-J.; Liaw, C.-C.; Lin, Y.-C.; Nguyen, N.-L.; Vo, T.-H.; Cheng, Y.-Y.; Morris-Natschke, S.L.; Lee, K.-H.; Kuo, Y.-H. New Dammarane-Type Saponins from Gynostemma pentaphyllum. Molecules 2019, 24, 1375.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top