New Dammarane-Type Saponins from Gynostemma pentaphyllum
Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Department of Research and Development, Starsci Biotech Co. Ltd., Taipei 112, Taiwan
The Ph.D. Program in Clinical Drug Development of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Francesco Epifano
Received: 23 February 2019 / Revised: 27 March 2019 / Accepted: 5 April 2019 / Published: 8 April 2019
PDF [809 KB, uploaded 12 April 2019]
Six new dammarane-type saponins, gypenosides CP1-6 (1
), along with 19 known compounds 7
, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum
. Among these compounds, eight dammarane-type saponins, 2
, and 15,
exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).
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Chen, P.-Y.; Chang, C.-C.; Huang, H.-C.; Zhang, L.-J.; Liaw, C.-C.; Lin, Y.-C.; Nguyen, N.-L.; Vo, T.-H.; Cheng, Y.-Y.; Morris-Natschke, S.L.; Lee, K.-H.; Kuo, Y.-H. New Dammarane-Type Saponins from Gynostemma pentaphyllum. Molecules 2019, 24, 1375.
Chen P-Y, Chang C-C, Huang H-C, Zhang L-J, Liaw C-C, Lin Y-C, Nguyen N-L, Vo T-H, Cheng Y-Y, Morris-Natschke SL, Lee K-H, Kuo Y-H. New Dammarane-Type Saponins from Gynostemma pentaphyllum. Molecules. 2019; 24(7):1375.
Chen, Po-Yen; Chang, Chih-Chao; Huang, Hui-Chi; Zhang, Li-Jie; Liaw, Chia-Ching; Lin, Yu-Chi; Nguyen, Nham-Linh; Vo, Thanh-Hoa; Cheng, Yung-Yi; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung; Kuo, Yao-Haur. 2019. "New Dammarane-Type Saponins from Gynostemma pentaphyllum." Molecules 24, no. 7: 1375.
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