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Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology

1
Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, Portugal
2
Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, 1649-028 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
These authors contribute equally.
Molecules 2019, 24(7), 1350; https://doi.org/10.3390/molecules24071350
Received: 19 March 2019 / Revised: 1 April 2019 / Accepted: 3 April 2019 / Published: 5 April 2019
(This article belongs to the Special Issue Emerging Topics in (Endo)Cannabinoid Signalling)
With the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeutic strategies focusing on more integrated, personalized and effective approaches. The prospect of using neural stem cells (NSC) as regenerative therapies is very promising, however several issues still need to be addressed. In particular, the potential actions of pharmacological agents used to modulate NSC activity are highly relevant. With the ongoing discussion of cannabinoid usage for medical purposes and reports drawing attention to the effects of cannabinoids on NSC regulation, there is an enormous, and yet, uncovered potential for cannabinoids as treatment options for several neurological disorders, specifically when combined with stem cell therapy. In this manuscript, we review in detail how cannabinoids act as potent regulators of NSC biology and their potential to modulate several neurogenic features in the context of pathophysiology. View Full-Text
Keywords: cannabinoids; neural stem cells; neurogenesis; regeneration; pathophysiology cannabinoids; neural stem cells; neurogenesis; regeneration; pathophysiology
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MDPI and ACS Style

Rodrigues, R.S.; Lourenço, D.M.; Paulo, S.L.; Mateus, J.M.; Ferreira, M.F.; Mouro, F.M.; Moreira, J.B.; Ribeiro, F.F.; Sebastião, A.M.; Xapelli, S. Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology. Molecules 2019, 24, 1350. https://doi.org/10.3390/molecules24071350

AMA Style

Rodrigues RS, Lourenço DM, Paulo SL, Mateus JM, Ferreira MF, Mouro FM, Moreira JB, Ribeiro FF, Sebastião AM, Xapelli S. Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology. Molecules. 2019; 24(7):1350. https://doi.org/10.3390/molecules24071350

Chicago/Turabian Style

Rodrigues, Rui S.; Lourenço, Diogo M.; Paulo, Sara L.; Mateus, Joana M.; Ferreira, Miguel F.; Mouro, Francisco M.; Moreira, João B.; Ribeiro, Filipa F.; Sebastião, Ana M.; Xapelli, Sara. 2019. "Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology" Molecules 24, no. 7: 1350. https://doi.org/10.3390/molecules24071350

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