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Molecules 2019, 24(6), 1051; https://doi.org/10.3390/molecules24061051

Influence of Thiazolidine-2,4-Dione Derivatives with Azolidine or Thiosemicarbazone Moieties on Haemophilus spp. Planktonic or Biofilm-Forming Cells

1
Department of Organic Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 4A Chodźki, 20-093 Lublin, Poland
2
Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 1 Chodźki, 20-093 Lublin, Poland
*
Author to whom correspondence should be addressed.
Received: 18 February 2019 / Revised: 7 March 2019 / Accepted: 14 March 2019 / Published: 17 March 2019
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Biofilm, naturally formed by microorganisms as integrated surface-bound communities, is one of the reasons for the development of antimicrobial resistance. Haemophilus spp. are common and representative opportunistic Gram-negative rods forming from the upper respiratory tract microbiota. The aim of this paper was to evaluate the influence of thiazolidine-2,4-dionebased azolidine and chlorophenylthiosemicarbazone hybrids against both planktonic and biofilm-forming Haemophilus spp. cells. The in vitro activity against planktonic and biofilm-forming cells of the tested compounds were evaluated by using the broth microdilution method. These activities were detected against reference and clinical strains of Haemophilus spp. on the basis of MICs (minimal inhibitory concentrations) and MBICs (minimal biofilm inhibitory concentrations). In addition, anti-adhesive properties of these compounds were examined. The target compounds showed potential activity against planktonic cells with MIC = 62.5–500 mg/L and biofilm-forming cells with MBIC = 62.5–1000 mg/L. The observed anti-adhesive properties of the tested compounds were reversible during long-term incubation in a lower concentration of compounds. View Full-Text
Keywords: Haemophilus spp.; thiazolidine-2,4-dione based azolidine and chlorophenylthiosemicarbazone hybrids; anti-planktonic and antibiofilm activity; anti-adhesive properties Haemophilus spp.; thiazolidine-2,4-dione based azolidine and chlorophenylthiosemicarbazone hybrids; anti-planktonic and antibiofilm activity; anti-adhesive properties
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Trotsko, N.; Kosikowska, U.; Andrzejczuk, S.; Paneth, A.; Wujec, M. Influence of Thiazolidine-2,4-Dione Derivatives with Azolidine or Thiosemicarbazone Moieties on Haemophilus spp. Planktonic or Biofilm-Forming Cells. Molecules 2019, 24, 1051.

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