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The Concept of an Ideal Antibiotic: Implications for Drug Design

Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary
Molecules 2019, 24(5), 892; https://doi.org/10.3390/molecules24050892
Received: 5 February 2019 / Revised: 21 February 2019 / Accepted: 27 February 2019 / Published: 3 March 2019
(This article belongs to the Special Issue Chemical Biology of Antimicrobial Resistance)
The emergence and spread of antibiotic-resistant pathogens is a major public health issue, which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens—especially “ESKAPE” bacteria—can withstand lethal doses of antibiotics with various chemical structures and mechanisms of action. Pharmaceutical companies are increasingly turning away from participating in the development of new antibiotics, due to the regulatory environment and the financial risks. There is an urgent need for innovation in antibiotic research, as classical discovery platforms (e.g., mining soil Streptomycetes) are no longer viable options. In addition to discovery platforms, a concept of an ideal antibiotic should be postulated, to act as a blueprint for future drugs, and to aid researchers, pharmaceutical companies, and relevant stakeholders in selecting lead compounds. Based on 150 references, the aim of this review is to summarize current advances regarding the challenges of antibiotic drug discovery and the specific attributes of an ideal antibacterial drug (a prodrug or generally reactive compound with no specific target, broad-spectrum antibacterial activity, adequate penetration through the Gram-negative cell wall, activity in biofilms and in hard-to-treat infections, accumulation in macrophages, availability for oral administration, and for use in sensitive patient groups). View Full-Text
Keywords: antibiotic; multidrug-resistance; drug discovery; ESKAPE; prodrug; persisters; biofilm; metronidazole; Mycobacterium antibiotic; multidrug-resistance; drug discovery; ESKAPE; prodrug; persisters; biofilm; metronidazole; Mycobacterium
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MDPI and ACS Style

Gajdács, M. The Concept of an Ideal Antibiotic: Implications for Drug Design. Molecules 2019, 24, 892. https://doi.org/10.3390/molecules24050892

AMA Style

Gajdács M. The Concept of an Ideal Antibiotic: Implications for Drug Design. Molecules. 2019; 24(5):892. https://doi.org/10.3390/molecules24050892

Chicago/Turabian Style

Gajdács, Márió. 2019. "The Concept of an Ideal Antibiotic: Implications for Drug Design" Molecules 24, no. 5: 892. https://doi.org/10.3390/molecules24050892

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