Next Article in Journal
Natural Products Containing ‘Rare’ Organophosphorus Functional Groups
Next Article in Special Issue
Enantiomeric Tartaric Acid Production Using cis-Epoxysuccinate Hydrolase: History and Perspectives
Previous Article in Journal
Facile Access to Fe(III)-Complexing Cyclic Hydroxamic Acids in a Three-Component Format
Previous Article in Special Issue
Enhanced Near-Field Chirality in Periodic Arrays of Si Nanowires for Chiral Sensing
Article Menu
Issue 5 (March-1) cover image

Export Article

Open AccessReview
Molecules 2019, 24(5), 865; https://doi.org/10.3390/molecules24050865

Chiral Stationary Phases for Liquid Chromatography: Recent Developments

1
Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
2
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal
3
Cooperativa de Ensino Superior, Politécnico e Universitário (CESPU), Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal
*
Author to whom correspondence should be addressed.
Received: 31 January 2019 / Revised: 17 February 2019 / Accepted: 26 February 2019 / Published: 28 February 2019
Full-Text   |   PDF [1992 KB, uploaded 4 March 2019]   |  

Abstract

The planning and development of new chiral stationary phases (CSPs) for liquid chromatography (LC) are considered as continuous and evolutionary issues since the introduction of the first CSP in 1938. The main objectives of the development strategies were to attempt the improvement of the chromatographic enantioresolution performance of the CSPs as well as enlarge their versatility and range of applications. Additionally, the transition to ultra-high-performance LC were underscored. The most recent strategies have comprised the introduction of new chiral selectors, the use of new materials as chromatographic supports or the reduction of its particle size, and the application of different synthetic approaches for preparation of CSPs. This review gathered the most recent developments associated to the different types of CSPs providing an overview of the relevant advances that are arising on LC. View Full-Text
Keywords: liquid chromatography; enantioseparation; chiral stationary phase; chiral selector; chromatographic support liquid chromatography; enantioseparation; chiral stationary phase; chiral selector; chromatographic support
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Teixeira, J.; Tiritan, M.E.; Pinto, M.M.M.; Fernandes, C. Chiral Stationary Phases for Liquid Chromatography: Recent Developments. Molecules 2019, 24, 865.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top