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Molecules 2019, 24(5), 859; https://doi.org/10.3390/molecules24050859

Using UHPLC-MS Profiling for the Discovery of New Dihydro-β-Agarofurans from Australian Celastraceae Plant Extracts

1
Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia
2
Queensland Herbarium, Brisbane Botanic Gardens, Toowong, QLD 4066, Australia
3
Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Melbourne, VIC 3010, Australia
*
Author to whom correspondence should be addressed.
Received: 1 February 2019 / Revised: 19 February 2019 / Accepted: 20 February 2019 / Published: 28 February 2019
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Abstract

An analytical method using UHPLC-MS was developed and applied to 16 crude CH2Cl2 extracts from Australian Celastraceae plants; the endemic plant materials were accessed from Griffith University’s NatureBank resource and included bark, fruit, leaf, root, twig and mixed samples, all of which were collected from Queensland, Australia. The generated UHPLC-MS data were analysed and dereplicated using the scientific databases Dictionary of Natural Products and SciFinder Scholar in order to potentially identify new dihydro-β-agarofurans from local Celastraceae plants. These investigations led to the large-scale extraction and isolation work on a prioritised fruit sample that belonged to the rainforest plant Denhamia celastroides. Chemical investigations resulted in the purification of four new natural products, denhaminols O–R (14), along with the related and known compound, denhaminol G (5). The structures of all the new compounds were determined via detailed analysis of NMR and MS data. View Full-Text
Keywords: UHPLC-MS; Celastraceae; dihydro-β-agarofuran; sesquiterpenoid; Denhamia celastroides; NMR UHPLC-MS; Celastraceae; dihydro-β-agarofuran; sesquiterpenoid; Denhamia celastroides; NMR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wibowo, M.; Forster, P.I.; Guymer, G.P.; Hofmann, A.; Davis, R.A. Using UHPLC-MS Profiling for the Discovery of New Dihydro-β-Agarofurans from Australian Celastraceae Plant Extracts. Molecules 2019, 24, 859.

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