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Molecules 2019, 24(4), 677; https://doi.org/10.3390/molecules24040677

Recovery of Oligomeric Proanthocyanidins and Other Phenolic Compounds with Established Bioactivity from Grape Seed By-Products

1
Interdepartmental Centre for Agri-Food Industrial Research, University of Bologna, via Quinto Bucci 336, 47521 Cesena (FC), Italy
2
Department of Agricultural and Food Sciences, University of Bologna, Piazza Goidanich 60, 47521 Cesena (FC), Italy
3
Department of Nutrition and Food Science, University of Granada, Campus of Cartuja, 18071 Granada, Spain
4
Institute of Nutrition and Food Technology (INYTA) ‘José Mataix’, Biomedical Research Centre, University of Granada, Avenida del Conocimiento s/n, E-18071 Granada, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Luisella Verotta and Alessandra Napolitano
Received: 17 January 2019 / Revised: 5 February 2019 / Accepted: 11 February 2019 / Published: 14 February 2019
(This article belongs to the Special Issue Bioactives from Bioprocessing: Sources and Production)
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Abstract

Grape seeds are a copious part of the grape pomace produced by wine and juice industry and they represent an interesting source of phenolic compounds. Proanthocyanidins (PAs) are the main class of grape seed phenols and are important dietary supplements for their well-known beneficial properties. In this study enriched extracts obtained from Chardonnay and Pignoletto grape seeds were characterized for their proanthocyanidins and other minor phenolic compounds content and composition. Seed PAs were fractionated using Sephadex LH-20, using different ethanol aqueous solutions as mobile phase and analysed by normal phase HPLC-FLD-ESI-MS. Monomers, oligomers up to dodecamers and polymers were recorded in all samples. For both cultivars, the extracts showed a high content in PAs. The determination of other phenolic compounds was carried out using a HPLC-QqQ-ESI-MS and Chardonnay samples reported a greater content compared to Pignoletto samples. Contrary to PAs fraction, extracts obtained with ethanol/water 50/50 (v/v) presented a significant higher phenolic content than the others. View Full-Text
Keywords: grape seeds; flavan-3-ols; oligomeric proanthocyanidins; phenolic compounds; LH-20 Sephadex grape seeds; flavan-3-ols; oligomeric proanthocyanidins; phenolic compounds; LH-20 Sephadex
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pasini, F.; Chinnici, F.; Caboni, M.F.; Verardo, V. Recovery of Oligomeric Proanthocyanidins and Other Phenolic Compounds with Established Bioactivity from Grape Seed By-Products. Molecules 2019, 24, 677.

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