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Open AccessArticle

Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T2 Weighted Magnetic Resonance Imaging

1
CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse CEDEX 4, France
2
Université de Toulouse, UPS, INPT, F-31077 Toulouse CEDEX 4, France
3
LPCNO, INSA, 135 Avenue de Rangueil, 31077 Toulouse CEDEX 4, France
4
Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 19 avenue Maistriau, B- 7000 Mons, Belgium
5
Center for Microscopy and Molecular Imaging (CMMI), Université de Mons (UMONS), Charleroi, Belgium
6
Departament de Química, Universitat Autònoma de Barcelona (UAB), Campus UAB, 08193 Cerdanyola del Vallès, Barcelona, Spain
7
Institut de Biotecnologia i Biomedicina, Departament de Bioquimica i de Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(24), 4629; https://doi.org/10.3390/molecules24244629
Received: 25 October 2019 / Revised: 13 December 2019 / Accepted: 13 December 2019 / Published: 17 December 2019
(This article belongs to the Special Issue Nanomaterials for Cancer Diagnosis and Therapy)
The growing concern over the toxicity of Gd-based contrast agents used in magnetic resonance imaging (MRI) motivates the search for less toxic and more effective alternatives. Among these alternatives, iron–iron oxide ([email protected]) core-shell architectures have been long recognized as promising MRI contrast agents while limited information on their engineering is available. Here we report the synthesis of 10 nm large [email protected] nanoparticles, their coating with a 11 nm thick layer of dense silica and functionalization by 5 kDa PEG chains to improve their biocompatibility. The nanomaterials obtained have been characterized by a set of complementary techniques such as infra-red and nuclear magnetic resonance spectroscopies, transmission electron microscopy, dynamic light scattering and zetametry, and magnetometry. They display hydrodynamic diameters in the 100 nm range, zetapotential values around −30 mV, and magnetization values higher than the reference contrast agent RESOVIST®. They display no cytotoxicity against 1BR3G and HCT116 cell lines and no hemolytic activity against human red blood cells. Their nuclear magnetic relaxation dispersion (NMRD) profiles are typical for nanomaterials of this size and magnetization. They display high r2 relaxivity values and low r1 leading to enhanced r2/r1 ratios in comparison with RESOVIST®. All these data make them promising contrast agents to detect early stage tumors. View Full-Text
Keywords: nanomaterials; nanochemistry; surface functionalization; MRI; toxicity nanomaterials; nanochemistry; surface functionalization; MRI; toxicity
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Mathieu, P.; Coppel, Y.; Respaud, M.; Nguyen, Q.T.; Boutry, S.; Laurent, S.; Stanicki, D.; Henoumont, C.; Novio, F.; Lorenzo, J.; Montpeyó, D.; Amiens, C. Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T2 Weighted Magnetic Resonance Imaging. Molecules 2019, 24, 4629.

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