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Open AccessArticle

Convergent Synthesis of Polysubstituted Furans via Catalytic Phosphine Mediated Multicomponent Reactions

by Xia Fan 1, Rongshun Chen 2,*, Jie Han 1 and Zhengjie He 1,*
1
The State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
2
Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, China
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(24), 4595; https://doi.org/10.3390/molecules24244595
Received: 15 November 2019 / Revised: 10 December 2019 / Accepted: 13 December 2019 / Published: 16 December 2019
(This article belongs to the Section Organic Chemistry)
Tri- or tetrasubstituted furans have been prepared from terminal activated olefins and acyl chlorides or anhydrides by a multicomponental convergent synthesis mode. Instead of stoichiometric nBu3P, only catalytic nBu3P or nBu3P=O is needed to furnish the furans in modest to excellent yields with a good functional group tolerance under the aid of reducing agent silane. This synthetic method features a silane-driven catalytic intramolecular Wittig reaction as a key annulation step and represents the first successful application of catalytic Wittig reaction in multicomponent cascade reaction. View Full-Text
Keywords: polysubstituted furans; multicomponent reaction; silanes; phosphine oxides; catalytic Wittig reaction polysubstituted furans; multicomponent reaction; silanes; phosphine oxides; catalytic Wittig reaction
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MDPI and ACS Style

Fan, X.; Chen, R.; Han, J.; He, Z. Convergent Synthesis of Polysubstituted Furans via Catalytic Phosphine Mediated Multicomponent Reactions. Molecules 2019, 24, 4595.

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