Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. General Experimental Procedures
3.2. Fungal Material
3.3. Fermentation
3.4. Extraction and Isolation
3.5. Antimicrobial Assays
3.6. Computational Section
4. Conclusions
Supplementary Materials
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples of the compounds 1–5 are available from the authors. |
1 | 2 | ||||
---|---|---|---|---|---|
No. | δH (Mult, J in Hz) a | δC, Type b | No. | δH (Mult, J in Hz) a | δC, Type b |
1 | - | - | 1 | - | 126.6, qC |
2 | - | 157.7, qC | 2 | - | 119.1, CH |
3 | - | - | 3 | 6.28, d (7.6) | 120.5, CH |
4 | - | 162.9, qC | 4 | 6.49, d (7.6) | 123.2, qC |
4a | - | 121.1, qC | 5 | - | 143.2, qC |
5 | 8.04, d (8.0) | 126.1, CH | 6 | - | 142.1, qC |
6 | 7.42, t (7.5) | 126.3, CH | 7 | - | 134.2, qC |
7 | 7.73, t (7.5) | 134.5, CH | 8 | 5.34, t (6.6) | 126.7, CH |
8 | 7.57, d (8.0) | 127.1, CH | 9 | 1.74, m | 26.3, CH2 |
8a | - | 149.5, qC | 10a | 1.54, m | 33.1, CH2 |
9 | 3.79, s | 40.7, CH2 | 10b | 1.33, m | - |
10 | - | 127.0, qC | 11 | 2.33, m | 38.0, CH |
11 | 7.14, d (7.8) | 130.2, CH | 12 | - | 176.1, qC |
12 | 6.70, d (7.8) | 115.7, CH | 13 | 0.94, d (6.6) | 16.1, CH3 |
13 | - | 157.0, qC | 14 | 1.88, s | 24.6, CH3 |
14 | 6.70, d (7.8) | 115.7, CH | 15 | 2.10, s | 16.5, CH3 |
15 | 7.14, d (7.8) | 130.2, CH | 1′ | 3.50, s | 51.1, CH3 |
1′ | - | 175.8, qC | |||
2′ | 1.67, s | 25.3, CH3 |
No. | δH (Mult, J in Hz) a | δC, Type b | No. | δH (Mult, J in Hz) a | δC, Type b |
---|---|---|---|---|---|
1 | - | 129.4, qC | 1′′ | - | 109.5, qC |
2 | 6.71, s | 135.0, CH | 2′′ | 1.46, m | 37.7, CH2 |
3 | 4.71, s | 71.7, CH | 3′′ | 1.51, m | 24.0, CH2 |
4 | 4.16, t (6.2) | 75.1, CH | 4′′ | 1.31, m | 25.0, CH2 |
5 | 3.72, m | 75.5, CH | 5′′ | 1.48, m | 23.8, CH2 |
6a | 2.26, dd (6.5, 17.4) | 26.8, CH2 | 6′′ | 1.52, m | 35.4, CH2 |
6b | 2.46, dd (6.5, 17.4) | ||||
7 | - | 166.6, qC | 1′′′ | 3.63, s | 52.0, CH3 |
1′ | 4.23, m | 73.8, CH | 1′′′′ | 3.68, s | 52.5, CH3 |
2′ | - | 173.6, qC | |||
3′ | 1.22, d (6.8) | 19.5, CH3 |
Strains | 1 | 2 | 3 | 4 | 5 | Positive Control |
---|---|---|---|---|---|---|
Escherichia colib | 16 | 2.0 | – | 8.0 | – | 2.0 |
Staphylococcus aureusb | 8.0 | 16 | – | 8.0 | 32 | 1.0 |
Staphylococcus. epidermidisb | 4.0 | 16 | 32 | 16 | – | 2.0 |
Streptococcus pneumoniaeb | 16 | 4.0 | 32 | 8.0 | 32 | 1.0 |
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Liu, Y.-J.; Zhang, J.-L.; Li, C.; Mu, X.-G.; Liu, X.-L.; Wang, L.; Zhao, Y.-C.; Zhang, P.; Li, X.-D.; Zhang, X.-X. Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9. Molecules 2019, 24, 4596. https://doi.org/10.3390/molecules24244596
Liu Y-J, Zhang J-L, Li C, Mu X-G, Liu X-L, Wang L, Zhao Y-C, Zhang P, Li X-D, Zhang X-X. Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9. Molecules. 2019; 24(24):4596. https://doi.org/10.3390/molecules24244596
Chicago/Turabian StyleLiu, Yu-Jing, Jian-Long Zhang, Chen Li, Xue-Gen Mu, Xiao-Li Liu, Lei Wang, Yan-Cui Zhao, Peng Zhang, Xiao-Dong Li, and Xing-Xiao Zhang. 2019. "Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9" Molecules 24, no. 24: 4596. https://doi.org/10.3390/molecules24244596