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Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9

1
Key Laboratory of marine biotechnology in Universities of Shandong (Ludong University), School of Life Sciences, Ludong University, Yantai 264025, China
2
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
3
Shandong Provincial Key Laboratory of Quality Safty Monitoring and Risk Assessment for Animal Products, Ji’nan 250022, China
4
Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266101, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Francisco Leon
Molecules 2019, 24(24), 4596; https://doi.org/10.3390/molecules24244596
Received: 21 November 2019 / Revised: 5 December 2019 / Accepted: 11 December 2019 / Published: 16 December 2019
(This article belongs to the Special Issue Natural Products from Fungi)
Marine-derived fungi are considered to be valuable producers of bioactive secondary metabolites used as lead compounds with medicinal importance. In this study, chemical investigation of the seawater-derived fungus Aspergillus sydowii SW9 led to the isolation and identification of one new quinazolinone alkaloid, 2-(4-hydroxybenzyl)-4-(3-acetyl)quinazolin-one (1), one new aromatic bisabolene-type sesquiterpenoid, (2) and one new chorismic acid analogue (3), as well as two known alkaloids (compounds 4 and 5). Their structures were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of 2 and 3 were assigned by the analysis of ECD spectra aided by quantum chemical computations. Compounds 1, 2, and 4 exhibited selective inhibitory activities against the human pathogenic bacteria Escherichia coli, Staphylococcus aureus, S. epidermidis, and Streptococcus pneumoniae, with MIC values ranging from 2.0 to 16 μg/mL. View Full-Text
Keywords: Aspergillus sydowii; seawater-derived fungus; secondary metabolites; antimicrobial activity Aspergillus sydowii; seawater-derived fungus; secondary metabolites; antimicrobial activity
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MDPI and ACS Style

Liu, Y.-J.; Zhang, J.-L.; Li, C.; Mu, X.-G.; Liu, X.-L.; Wang, L.; Zhao, Y.-C.; Zhang, P.; Li, X.-D.; Zhang, X.-X. Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9. Molecules 2019, 24, 4596.

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