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Photocatalytic Difluoromethylation Reactions of Aromatic Compounds and Aliphatic Multiple C–C Bonds

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Orgánica, Junín 954, Buenos Aires CP1113, Argentina
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Academic Editor: Davide Ravelli
Molecules 2019, 24(24), 4483; https://doi.org/10.3390/molecules24244483
Received: 18 November 2019 / Revised: 1 December 2019 / Accepted: 5 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Photocatalytic Strategies in Organic Synthesis)
Among the realm of visible light photocatalytic transformations, late-stage difluoromethylation reactions (introduction of difluoromethyl groups in the last stages of synthetic protocols) have played relevant roles as the CF2X group substitutions exert positive impacts on the physical properties of organic compounds including solubility, metabolic stability, and lipophilicity, which are tenets of considerable importance in pharmaceutical, agrochemical, and materials science. Visible-light-photocatalyzed difluoromethylation reactions are shown to be accomplished on (hetero)aromatic and carbon–carbon unsaturated aliphatic substrates under mild and environmentally benign conditions. View Full-Text
Keywords: difluoromethylation; photocatalytic difluoromethylation; visible light; difluoromethyl-substituted (hetero)arenes; difluoromethylation of olefins difluoromethylation; photocatalytic difluoromethylation; visible light; difluoromethyl-substituted (hetero)arenes; difluoromethylation of olefins
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MDPI and ACS Style

Barata-Vallejo, S.; Postigo, A. Photocatalytic Difluoromethylation Reactions of Aromatic Compounds and Aliphatic Multiple C–C Bonds. Molecules 2019, 24, 4483.

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