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Open AccessArticle

Traceability of Geographical Origin in Gentiana straminea by UPLC-Q Exactive Mass and Multivariate Analyses

1
College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China
2
Qinghai Provincial Key Laboratory of Qinghai-Tibet Plateau Biological Resources, Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining 810008, China
3
Chongqing Academy of Chinese Materia Medica, Chongqing 404000, China
4
Centre for Academic Inheritance and Innovation of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611130, China
5
Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing 400016, China
*
Authors to whom correspondence should be addressed.
Zheng Pan and Feng Xiong are co-first authors.
Academic Editor: Ping-Chung Kuo
Molecules 2019, 24(24), 4478; https://doi.org/10.3390/molecules24244478
Received: 25 October 2019 / Revised: 3 December 2019 / Accepted: 4 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Food and Drug Analysis)
The root of Gentiana straminea Maxim. (Gentianaceae), is officially listed as “Qin-Jiao” in the Chinese Pharmacopoeia for the treatment of rheumatic arthritis, icteric hepatitis, constipation, pain, and hypertension. To establish the geographical origin traceability in G. straminea, its chemical profiles were determined by a UPLC-Q exactive mass spectrometer, from which 43 compounds were identified by comparing retention times and mass spectrometry. Meanwhile, a pair of isomers (loganin and secologanol) was identified by mass spectrometry based on their fragmentation pathway. A total of 42 samples from difference habitats were determined by an UPLC-Q exactive mass spectrometer and the data were assayed with multivariate statistical analysis. Eight characteristic compounds were identified to determine the geographical origin of the herb. To estimate the key characteristic markers associated with pharmacological function, the inhibiting activities of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced macrophages were examined. This finding is crucial in realizing the determination of botanical origin and evaluating the quality of G. straminea. View Full-Text
Keywords: Gentiana straminea; geographical origin; UPLC-Q exactive mass; metabolomics; multivariate analysis Gentiana straminea; geographical origin; UPLC-Q exactive mass; metabolomics; multivariate analysis
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Pan, Z.; Xiong, F.; Chen, Y.-L.; Wan, G.-G.; Zhang, Y.; Chen, Z.-W.; Cao, W.-F.; Zhou, G.-Y. Traceability of Geographical Origin in Gentiana straminea by UPLC-Q Exactive Mass and Multivariate Analyses. Molecules 2019, 24, 4478.

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