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Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development

1
Departament of Pharmacy, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
2
Departament of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa PB 58051-970, Brazil
3
Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa PB 58051-970, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Raffaele Pezzani
Molecules 2019, 24(24), 4469; https://doi.org/10.3390/molecules24244469
Received: 15 November 2019 / Revised: 28 November 2019 / Accepted: 28 November 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Biological and Pharmacological Activity of Plant Natural Compounds)
Depression is a health problem that compromises the quality of life of the world′s population. It has different levels of severity and a symptomatic profile that affects social life and performance in work activities, as well as a high number of deaths in certain age groups. In the search for new therapeutic options for the treatment of this behavioral disorder, the present review describes studies on antidepressant activity of cinnamic acids, which are natural products found in medicinal plants and foods. The description of the animal models used and the mechanisms of action of these compounds are discussed. View Full-Text
Keywords: natural products; phenylpropanoids; phenolic acids; plants; depression; behavioral disorders; forced swim test; tail suspension test natural products; phenylpropanoids; phenolic acids; plants; depression; behavioral disorders; forced swim test; tail suspension test
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Diniz, L.R.L.; Souza, M.T.S.; Barboza, J.N.; Almeida, R.N.; Sousa, D.P. Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development. Molecules 2019, 24, 4469.

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