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Open AccessArticle

Anti-Inflammatory Derivatives with Dual Mechanism of Action from the Metabolomic Screening of Poincianella pluviosa

1
Instituto de Química–Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil
2
Instituto Federal de de Educação, Ciência e Tecnologia do Sul de Minas Gerais-IFSULDEMINAS, Muzambinho 37890-000, MG, Brazil
3
Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo Andre 09606-045, SP, Brazil
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(23), 4375; https://doi.org/10.3390/molecules24234375
Received: 16 October 2019 / Revised: 8 November 2019 / Accepted: 16 November 2019 / Published: 29 November 2019
(This article belongs to the Section Natural Products Chemistry)
Metabolomics approaches have become fundamental strategies for the analysis of complex mixtures, guiding the isolation of target compounds by focusing on unpublished or promising pharmacological properties. The discovery of novel anti-inflammatory agents is important due to several limitations regarding their potency, efficacy, and adverse effects. Thus, novel anti-inflammatory candidates are essential, aiming to find agents with better mechanisms of action. In this context, extracts from Poincianella pluviosa var. peltophoroides demonstrated significant in vivo anti-inflammatory potential. Thus, metabolomics analysis based on UHPLC-UV-HRFTMS data was performed for the identification of biomarkers with anti-inflammatory properties. Metabolomics-guided chromatographic process led to the isolation of novel compounds 4‴-methoxycaesalpinioflavone and 7-methoxycaesalpinioflavone, as well as known derivatives rhuschalcone VI and caesalpinioflavone. Isolated compounds caused edema inhibition and neutrophil recruitment. Two of them showed better efficacy than reference drugs (indomethacin and dexamethasone). Results of in vivo experiments corroborated those obtained through metabolomics and statistical analyses guiding the isolation of substances of interest. View Full-Text
Keywords: Poincianella pluviosa; anti-inflammatory; flavonoids; metabolomics Poincianella pluviosa; anti-inflammatory; flavonoids; metabolomics
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Domingos, O.S.; Alcântara, B.G.V.; Santos, M.F.C.; Maiolini, T.C.S.; Dias, D.F.; Baldim, J.L.; Lago, J.H.G.; Soares, M.G.; Chagas-Paula, D.A. Anti-Inflammatory Derivatives with Dual Mechanism of Action from the Metabolomic Screening of Poincianella pluviosa. Molecules 2019, 24, 4375.

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