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Open AccessArticle

Antioxidant, Antimutagenic and Cytoprotective Properties of Hydrosos Pistachio Nuts

Departamento de Tecnología Agroalimentaria, Grupo Calidad y Seguridad Alimentaria (CSA), Escuela Politécnica Superior de Orihuela (EPSO), Universidad Miguel Hernández de Elche (UMH), Carretera de Beniel, km 3,2. 03312-Orihuela, Alicante, Spain
Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora 83000, Mexico
Author to whom correspondence should be addressed.
Academic Editor: Ladislav Kokoska
Molecules 2019, 24(23), 4362;
Received: 5 November 2019 / Revised: 25 November 2019 / Accepted: 26 November 2019 / Published: 29 November 2019
Pistachio nuts are included among the foods with the highest antioxidant capacity. Stressed cultivating conditions, such as the use of regulated deficit irrigation (RDI), are expected to create a plant response that might increase the production of secondary metabolites. Fruits that are obtained under RDI treatments are commonly called hydroSOS products. The aim of this work was to study the influence of using different rootstocks (P. atlantica, P. integerrima, and P. terebinthus) and two RDI treatments on the antioxidant (ABTS, ferric reducing antioxidant power (FRAP), and DPPH), antimutagenic (Ames test), and cytotoxicity (MTT assay in five human cell lines) activities of pistachios. P. terebinthus showed the best antioxidant activity, and the RDI treatments maintained and improved the antioxidant properties of pistachios. Neither the rootstock nor the RDI had significant impact on the antimutagenic potential of pistachios. The nut extracts had no toxic effect on non-cancerous cells and the application of RDI did not reduce their cytoprotective capacity. Furthermore, neither rootstock nor RDI treatments affected the ability of the pistachio extracts of preventing the oxidative damage by H2O2. The application of RDI strategies, in addition to allowing irrigation water saving, led to obtaining pistachios with the same or even better biofunctional characteristics as compared to fully irrigated pistachios. View Full-Text
Keywords: Ames test; cancer; rootstock; MTT assay; Pistacia vera Ames test; cancer; rootstock; MTT assay; Pistacia vera
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Noguera-Artiaga, L.; García-Romo, J.S.; Rosas-Burgos, E.C.; Cinco-Moroyoqui, F.J.; Vidal-Quintanar, R.L.; Carbonell-Barrachina, Á.A.; Burgos-Hernández, A. Antioxidant, Antimutagenic and Cytoprotective Properties of Hydrosos Pistachio Nuts. Molecules 2019, 24, 4362.

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