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Open AccessArticle

Organocatalytic Asymmetric Conjugate Addition of Aldehydes to Maleimides and Nitroalkenes in Deep Eutectic Solvents

Departamento de Química Orgánica, Facultad de Ciencias, and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain
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Academic Editor: Sven Mangelinckx
Molecules 2019, 24(22), 4058; https://doi.org/10.3390/molecules24224058
Received: 23 October 2019 / Revised: 7 November 2019 / Accepted: 7 November 2019 / Published: 9 November 2019
(This article belongs to the Special Issue Development of Asymmetric Synthesis)
A chiral primary amine-salicylamide is used as an organocatalyst for the enantioselective conjugate addition of α,α-disubstituted aldehydes to maleimides and nitroalkenes. The reactions are performed in deep eutectic solvents as reaction media at room temperature, leading to the corresponding adducts with enantioselectivities up to 88% (for maleimides) and 80% (for nitroalkenes). Catalyst and solvent can be recovered and reused. View Full-Text
Keywords: organocatalysis; deep eutectic solvents; conjugate addition; maleimides; nitroalkenes organocatalysis; deep eutectic solvents; conjugate addition; maleimides; nitroalkenes
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MDPI and ACS Style

Torregrosa-Chinillach, A.; Sánchez-Laó, A.; Santagostino, E.; Chinchilla, R. Organocatalytic Asymmetric Conjugate Addition of Aldehydes to Maleimides and Nitroalkenes in Deep Eutectic Solvents. Molecules 2019, 24, 4058.

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