Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment
Penicillium species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (
1), 3-indolecarbaldehyde (
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Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment
Penicillium species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (
1), 3-indolecarbaldehyde (
2), 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (
3), 2-[(2
R-hydroxypropanoyl)amino]benzamide (
4), 4-hydroxybenzandehyde (
5), chrysogine (
6), 3-acetyl-4-hydroxycinnoline (
7), acid 1H-indole-3-acetic (
8), cyclo (Tyr-Trp) (
9), and 2’,3’-dihydrosorbicillin (
10). Their structures were identified by the analysis of 1D and 2D NMR data. Among the isolated compounds, 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (
3) showed a strong inhibitory effect against
Enterococcus faecalis with a minimum inhibitory concentration value of 32 µg/mL. Both 2-[(2
R-hydroxypropanoyl)amino]benzamide (
4) and 4-hydroxybenzandehyde (
5) selectively inhibited
E. coli with minimum inhibitory concentration values of 16 and 8 µg/mL, respectively. 2’,3’-Dihydrosorbicillin (
10) potentially inhibited α-glucosidase activity at a concentration of 2.0 mM (66.31%).
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