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Open AccessArticle

Anti-Oxidant and Anti-Melanogenic Properties of Essential Oil from Peel of Pomelo cv. Guan Xi

by Wanying He 1,2, Xiaoyan Li 1,2, Ying Peng 1,2, Xiaoyan He 1,2 and Siyi Pan 1,2,*
1
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China
2
Key Laboratory of Environment Correlative Dietology, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, Hubei, China
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(2), 242; https://doi.org/10.3390/molecules24020242
Received: 20 November 2018 / Revised: 4 January 2019 / Accepted: 7 January 2019 / Published: 10 January 2019
(This article belongs to the Special Issue Natural Additives in Food)
Here, we investigated the anti-oxidant and anti-melanogenic effects of pomelo peel essential oil (PPEO) from pomelo cv. Guan Xi. The volatile chemical composition of PPEO was analyzed with gas chromatography–mass spectrometry (GC/MS). The most abundant component of PPEO was limonene (55.92%), followed by β-myrcene (31.17%), and β-pinene (3.16%). PPEO showed strong anti-oxidant activities against 2,2-diphenyl-2-picryhydrazyl (DPPH), 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate (ABTS) and superoxide anion free radicals. Based on the B16 melanoma cell system, the effects of PPEO on the viability and morphology of B16 cells and the production of melanin were evaluated. The results revealed that PPEO at concentrations below 50 μg/mL could decrease the melanin content without affecting cell viability and morphology. Intracellular tyrosinase (TYR) activity and Western blot analysis showed that PPEO could down-regulate the expression level of TYR in B16 cells and dose-dependently inhibit TYR activity (by a maximum of 64.54%). In conclusion, PPEO has good anti-oxidant and anti-melanogenic activity, and thus can be widely used as a natural antioxidant in the food, pharmaceutical, and cosmetic industries. View Full-Text
Keywords: pomelo peel; essential oil; anti-oxidant; anti-melanogenic; B16 melanoma cell pomelo peel; essential oil; anti-oxidant; anti-melanogenic; B16 melanoma cell
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MDPI and ACS Style

He, W.; Li, X.; Peng, Y.; He, X.; Pan, S. Anti-Oxidant and Anti-Melanogenic Properties of Essential Oil from Peel of Pomelo cv. Guan Xi. Molecules 2019, 24, 242.

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