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Molecules 2019, 24(2), 230;

MicroRNAs as a Novel Tool in the Diagnosis of Liver Lipid Dysregulation and Fatty Liver Disease

Shenzhen University Medical Center, Shenzhen University Health Science Center, Shenzhen 518060, China
Department of Biology, Guangdong Pharmaceutical University, Guangzhou 510006, China
Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 11 November 2018 / Revised: 23 December 2018 / Accepted: 24 December 2018 / Published: 9 January 2019
(This article belongs to the Special Issue Application of Novel Method in Pharmaceutical Study)
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In recent years, metabolic disorder, especially fatty liver disease, has been considered a major challenge to global health. The attention of researchers focused on expanding knowledge of the regulation mechanism behind these diseases and towards the new diagnostics tools and treatments. The pathophysiology of the fatty liver disease is undoubtedly complex. Abnormal hepatic lipid accumulation is a major symptom of most metabolic diseases. Therefore, the identification of novel regulation factors of lipid metabolism is important and meaningful. As a new diagnostic tool, the function of microRNAs during fatty liver disease has recently come into notice in biological research. Accumulating evidence supports the influence of miRNAs in lipid metabolism. In this review, we discuss the potential role of miRNAs in liver lipid metabolism and the pathogenesis of fatty liver disease. View Full-Text
Keywords: microRNA; fatty liver disease; lipogenesis microRNA; fatty liver disease; lipogenesis

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Yu, J.; Peng, J.; Luan, Z.; Zheng, F.; Su, W. MicroRNAs as a Novel Tool in the Diagnosis of Liver Lipid Dysregulation and Fatty Liver Disease. Molecules 2019, 24, 230.

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