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Molecules 2019, 24(2), 228;

Palladium-Catalysed Synthesis and Transformation of Quinolones

Department of Chemistry QOPNA and LAQV-REQUIMTE, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal
Author to whom correspondence should be addressed.
Received: 9 December 2018 / Revised: 31 December 2018 / Accepted: 4 January 2019 / Published: 9 January 2019
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Palladium-catalysed reactions have had a large impact on synthetic organic chemistry and have found many applications in target-oriented synthesis. Their widespread use in organic synthesis is due to the mild conditions associated with the reactions together with their tolerance of a wide range of functional groups. Moreover, these types of reactions allow the rapid construction of complex molecules through multiple bond-forming reactions in a single step, the so-called tandem processes. Pd-catalysed reactions have been applied to the synthesis of a large number of natural products and bioactive compounds, some of them of complex molecular structures. This review article aims to present an overview of the most important Pd-catalysed reactions employed in the synthesis and transformations of quinolin-2(1H)-ones and quinolin-4(1H)-ones. These compounds are widely recognized by their diverse bioactivity, being privileged structures in medicinal chemistry and useful structural moieties for the development of new drug candidates. Furthermore, they hold significant interest due to their host–guest chemistry; applications in chemical, biochemical and environmental analyses and use in the development of new synthetic methods. In some cases, the quinolone formation step cannot be ascribed to a claimed Pd-catalysed reaction but this reaction is crucial to get the appropriate substrate for cyclization into the quinolone. Herein we present and discuss different economical, efficient and selective synthetic strategies to access quinolone-type compounds.
Keywords: palladium; Pd-catalysed; transition-metal catalysis; quinolones; heterocycles; reaction mechanism. palladium; Pd-catalysed; transition-metal catalysis; quinolones; heterocycles; reaction mechanism.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Silva, V.L.M.; Silva, A.M.S. Palladium-Catalysed Synthesis and Transformation of Quinolones. Molecules 2019, 24, 228.

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