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A Beta/ZSM-22 Zeolites-Based-Mixed Matrix Solid-Phase Dispersion Method for the Simultaneous Extraction and Determination of Eight Compounds with Different Polarities in Viticis Fructus by High-Performance Liquid Chromatography

by Gaogao He 1,2,†, Jin Li 1,†, Xiaoli Pang 3, Hui Wang 1,2, Hua Jin 1,2, Jun He 1,2, Shi-Ming Fang 2,* and Yan-Xu Chang 1,2,*
1
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
2
Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
3
Academy of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(19), 3423; https://doi.org/10.3390/molecules24193423
Received: 1 September 2019 / Revised: 11 September 2019 / Accepted: 19 September 2019 / Published: 20 September 2019
(This article belongs to the Section Analytical Chemistry)
Viticis Fructus (VF) was named Manjingzi as a commonly used traditional Chinese medicine (TCM) targeting various pains and inflammation for more than 2000 years. To guarantee the quality of Viticis Fructus, a simple, quick and eco-friendly Beta/ZSM-22 zeolites-based-mixed matrix solid-phase dispersion method (B/Z-MMSPD) was established for simultaneous extraction and determination of eight compounds (two phenolic acids, two iridoid glycosides, vanillin and three flavonoids) with different polarities from Viticis Fructus by high performance liquid chromatography coupled with a diode array detector (HPLC-DAD). Beta and ZSM-22 were mixed as the sorbent. Water, tetrahydrofuran and methanol were blended with certain ratio as the eluent. Several parameters including types of sorbents, mass ratio of Beta to ZSM-22, mass ratio of matrix to sorbent, grinding time, types, concentration and volume of eluent were optimized. The recoveries of eight analytes were within the range of 95.0%–105% (RSDs ≤ 4.13%). The limits of detection and limits of quantitation ranged from 0.5 to 5.5 μg/g and from 1.5 to 16 μg/g, respectively. Compared to the traditional extract methods, it was a simple, rapid, efficient and green method. The results demonstrated that a simple, rapid, efficient and green B/Z-MMSPD was developed for the simultaneous extraction and determination of eight target analytes with different polarities for quality control of Viticis Fructus. View Full-Text
Keywords: Beta/ZSM-22 zeolites-based-mixed matrix solid-phase dispersion; flavonoids; HPLC; iridoid glycosides; phenolic acids; vanillin; Viticis Fructus Beta/ZSM-22 zeolites-based-mixed matrix solid-phase dispersion; flavonoids; HPLC; iridoid glycosides; phenolic acids; vanillin; Viticis Fructus
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MDPI and ACS Style

He, G.; Li, J.; Pang, X.; Wang, H.; Jin, H.; He, J.; Fang, S.-M.; Chang, Y.-X. A Beta/ZSM-22 Zeolites-Based-Mixed Matrix Solid-Phase Dispersion Method for the Simultaneous Extraction and Determination of Eight Compounds with Different Polarities in Viticis Fructus by High-Performance Liquid Chromatography. Molecules 2019, 24, 3423.

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