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Open AccessReview

Neuroprotective Potential of Secondary Metabolites from Melicope lunu-ankenda (Rutaceae)

1
Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
2
Department of Biology, Faculty of Science, El-Mergib University, El Khums, Libya
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IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy
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Université d’Orléans et CNRS, ICOA, UMR 7311, BP 6759, F-45067 Orléans, France
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Chemistry Department, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
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Laboratory of Food Safety and Food Integrity, Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
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Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editors: Federica Pellati, Laura Mercolini and Roccaldo Sardella
Molecules 2019, 24(17), 3109; https://doi.org/10.3390/molecules24173109
Received: 8 June 2019 / Revised: 16 July 2019 / Accepted: 19 July 2019 / Published: 27 August 2019
Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. Melicope lunu-ankenda is one Melicope species (family Rutaceae), which is widely used in traditional medicine, consumed as a salad and a food seasoning. Consumption of different parts of this plant has been reported to exert different biological activities such as antioxidant and anti-inflammatory qualities, resulting in a protective effect against several health disorders including neurodegenerative diseases. Various secondary metabolites such as phenolic acid derivatives, flavonoids, coumarins and alkaloids, isolated from the M. lunu-ankenda plant, were demonstrated to have neuroprotective activities and also exert many other beneficial biological effects. A number of studies have revealed different neuroprotective mechanisms for these secondary metabolites. This review summarizes the most significant and recent studies for neuroprotective activity of M. lunu-ankenda major secondary metabolites in neurodegenerative diseases. View Full-Text
Keywords: polyphenols; coumarins; alkaloids; Melicope lunu-ankenda; neuroprotection; neurodegenerative diseases polyphenols; coumarins; alkaloids; Melicope lunu-ankenda; neuroprotection; neurodegenerative diseases
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Abdulwanis Mohamed, Z.; Mohamed Eliaser, E.; Mazzon, E.; Rollin, P.; Cheng Lian Ee, G.; Abdull Razis, A.F. Neuroprotective Potential of Secondary Metabolites from Melicope lunu-ankenda (Rutaceae). Molecules 2019, 24, 3109.

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