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Label-Free Exosomal Detection and Classification in Rapid Discriminating Different Cancer Types Based on Specific Raman Phenotypes and Multivariate Statistical Analysis

College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
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Authors to whom correspondence should be addressed.
Molecules 2019, 24(16), 2947; https://doi.org/10.3390/molecules24162947
Received: 22 July 2019 / Revised: 8 August 2019 / Accepted: 12 August 2019 / Published: 14 August 2019
(This article belongs to the Section Macromolecular Chemistry)
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Abstract

Exosomes contain different functional bimolecular characteristics related to physiological or pathological processes and are now recognized as new biomarkers in different human cancers. Rapid detection and classification of cancer-related exosomes might be helpful in the rapid screening of patients that may have cancer. Here, we report a surface enhanced Raman scattering technology for rapid and label-free exosomal detection (Exo-SERS) to aid in the discrimination of different cancer cells based on specific Raman phenotypes and multivariate statistical analysis. The results demonstrated that exosomes derived from both tumor cells and normal cells exhibit special, unique Raman phenotypes. Using the Exo-SERS method, the cancer cells were accurately discriminated from normal cells, and subtle molecular changes between the different cell types could be detected with high sensitive. This research provides a rapid, label-free and non-destructive manner for detecting and discriminating between cancer types. View Full-Text
Keywords: exosomes; biomarker; surface enhanced Raman scattering; cancer; Raman phenotype; rapid detection; label-free exosomes; biomarker; surface enhanced Raman scattering; cancer; Raman phenotype; rapid detection; label-free
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zhang, P.; Wang, L.; Fang, Y.; Zheng, D.; Lin, T.; Wang, H. Label-Free Exosomal Detection and Classification in Rapid Discriminating Different Cancer Types Based on Specific Raman Phenotypes and Multivariate Statistical Analysis. Molecules 2019, 24, 2947.

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