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Recent Advances in the Synthesis of 2H-Pyrans

1
Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain
2
Doctoral and Postgraduate School, Universidad de La Laguna, Astrofísico Francisco Sánchez, SN, 38200 La Laguna, Tenerife, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Gianfranco Favi
Molecules 2019, 24(16), 2904; https://doi.org/10.3390/molecules24162904
Received: 25 July 2019 / Revised: 8 August 2019 / Accepted: 9 August 2019 / Published: 9 August 2019
(This article belongs to the Special Issue Modern Strategies for Heterocycle Synthesis)
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Abstract

In this review, we discuss the nature of the different physicochemical factors affecting the valence isomerism between 2H-pyrans (2HPs) and 1-oxatrienes, and we describe the most versatile synthetic methods reported in recent literature to access to 2HPs, with the only exception of 2HPs fused to aromatic rings (i.e., 2H-chromenes), which are not included in this review. View Full-Text
Keywords: 2H-pyran; heterocycles; synthesis; valence isomerism; 1-oxa-triene; dienone; oxa-electrocyclization; Knoevenagel; propargyl Claisen; cycloisomerization 2H-pyran; heterocycles; synthesis; valence isomerism; 1-oxa-triene; dienone; oxa-electrocyclization; Knoevenagel; propargyl Claisen; cycloisomerization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Tejedor, D.; Delgado-Hernández, S.; Diana-Rivero, R.; Díaz-Díaz, A.; García-Tellado, F. Recent Advances in the Synthesis of 2H-Pyrans. Molecules 2019, 24, 2904.

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