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Ultrasonic Extraction of Tropane Alkaloids from Radix physochlainae Using as Extractant an Ionic Liquid with Similar Structure

1,†, 2,†, 1 and 1,*
1
School of Chemical Engineering, Sichuan University, Chengdu 610065, China
2
School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Brendan M Duggan
Molecules 2019, 24(16), 2897; https://doi.org/10.3390/molecules24162897
Received: 13 July 2019 / Revised: 1 August 2019 / Accepted: 8 August 2019 / Published: 9 August 2019
(This article belongs to the Special Issue Technology for Natural Products Research)
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Abstract

In this research, tropane alkaloids in Radix physochlainae were extracted by tropine-type ionic liquid (IL) aqueous solutions under ultrasound assistance, and N-propyltropine hexafluorophosphate ([C3Tr][PF6]) was found to be the most ideal IL in this extraction mode after comprehensive screening. When 0.03 mol/L [C3Tr][PF6] aqueous solution was chosen as the extraction solvent, the solid-liquid ratio of raw material powders and ionic liquid aqueous solution was 1:20 (g/mL), ultrasonic power was 90 W and extraction time was 30 min, the extraction efficiency of tropane alkaloids has reached 121.3%. Compared with common heating extraction, it can further shorten the extraction time, improve extraction efficiency and decrease IL consumption. Furthermore, extraction mechanism together with potential toxicity of IL have been explored and discussed. View Full-Text
Keywords: Radix physochlainae; tropane alkaloids; tropine ionic liquids; ultrasonic extraction Radix physochlainae; tropane alkaloids; tropine ionic liquids; ultrasonic extraction
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Yohannes, A.; Zhang, B.; Dong, B.; Yao, S. Ultrasonic Extraction of Tropane Alkaloids from Radix physochlainae Using as Extractant an Ionic Liquid with Similar Structure. Molecules 2019, 24, 2897.

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