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Open AccessArticle

The Antioxidant and Anti-Aging Effects of Acetylated Mycelia Polysaccharides from Pleurotus djamor

1
Dezhou Academy of Agricultural Sciences, Dezhou 253015, China
2
College of Life Science, Shandong Agricultural University, Taian 271018, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C.F.R. Ferreira
Molecules 2019, 24(15), 2698; https://doi.org/10.3390/molecules24152698
Received: 3 June 2019 / Revised: 24 June 2019 / Accepted: 14 July 2019 / Published: 24 July 2019
(This article belongs to the Collection Bioactive Compounds)
The present work mainly describes the preparation of acetylated mycelia polysaccharides (AMPS) from Pleurotus djamor and investigates the antioxidant and anti-aging effects in d-galactose-induced aging mice. The optimized procedure indicates the acetyl substitution degree of AMPS is 0.54 ± 0.04 under the conditions of a reaction time of 56 h, a reaction temperature of 37 °C, and 4 mL of added acetic anhydride. The in vitro analysis and in vivo animal experiments indicate that the AMPS could alleviate the aging properties by scavenging the radicals, elevating the enzyme activities, and reducing the lipid contents. As for serum levels, the AMPS can improve the serum biochemical indices and enhance immunological activity. The histopathological observations indicate that the injuries to the liver, kidney, and brain can be remitted by AMPS intervention. The characterization showed that AMPS was one kind of β-pyranose with the weight-average molecular weights of 3.61 × 105 Da and the major monosaccharides of mannose and glucose. The results suggest that AMPS can be used as a dietary supplement and functional food for the prevention of aging and age-related diseases. View Full-Text
Keywords: acetylated mycelia polysaccharides; Pleurotus djamor; antioxidant effects; anti-aging effects acetylated mycelia polysaccharides; Pleurotus djamor; antioxidant effects; anti-aging effects
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MDPI and ACS Style

Li, H.; Zhao, H.; Gao, Z.; Song, X.; Wang, W.; Yuan, F.; Feng, Y.; Zhang, Y.; Zhang, J.; Zhang, S.; Jia, L. The Antioxidant and Anti-Aging Effects of Acetylated Mycelia Polysaccharides from Pleurotus djamor. Molecules 2019, 24, 2698.

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