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Article

Mechanism Investigation of Tagetes patula L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology

1
College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
2
Department of Pharmacy, Shaheed Benazir Bhutto Sheringal Dir Upper, Khyber Pakhtoon Khwa 18000, Pakistan
3
College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
4
Dalian Wuzhou Holy Herb Scientific and Techonological Co. Ltd, Dalian 116600, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Francesco Maione
Molecules 2019, 24(12), 2266; https://doi.org/10.3390/molecules24122266
Received: 21 May 2019 / Revised: 15 June 2019 / Accepted: 17 June 2019 / Published: 18 June 2019
The major objective of this study was to investigate the anti-chronic nonbacterial prostatitis (CNP) mechanism of T. patula by metabolomics and network pharmacology. The study demonstrated that the flavonoids and polysaccharides of T. patula could alleviate prostatitis by improving the level of DHT, reducing the secretion of PSA and TNF-α. Besides, both could enhance Na+/K+-ATPase activity, decrease the O2 consumption, CO2 production, heat production, energy expenditure of rats and promote respiratory exchange ratio of rats. Up to 28 potential biomarkers and 8 key metabolic pathways related to the treatment of CNP were elucidated by the metabolomics analysis, including phenylalanine metabolism, taurine and hypotaurine metabolism, tryptophan metabolism etc. Network pharmacology prediction also reflected the potential mechanism was associated with tryptophan metabolism and energy pathway. Generally, the potential anti-CNP mechanism of flavonoids and polysaccharides of T. patula might be through reducing the expression of inflammation factors, adjusting the level of hormone and regulating the amino acid metabolism, energy metabolism and glucose and lipid metabolism. View Full-Text
Keywords: Tagetes patula L.; chronic nonbacterial prostatitis; metabolomics; energy metabolism; network pharmacology Tagetes patula L.; chronic nonbacterial prostatitis; metabolomics; energy metabolism; network pharmacology
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MDPI and ACS Style

Liu, X.; Ran, X.; Riaz, M.; Kuang, H.; Dou, D.; Cai, D. Mechanism Investigation of Tagetes patula L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology. Molecules 2019, 24, 2266. https://doi.org/10.3390/molecules24122266

AMA Style

Liu X, Ran X, Riaz M, Kuang H, Dou D, Cai D. Mechanism Investigation of Tagetes patula L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology. Molecules. 2019; 24(12):2266. https://doi.org/10.3390/molecules24122266

Chicago/Turabian Style

Liu, Xueying, Xiaoku Ran, Muhammad Riaz, Haixue Kuang, Deqiang Dou, and Decheng Cai. 2019. "Mechanism Investigation of Tagetes patula L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology" Molecules 24, no. 12: 2266. https://doi.org/10.3390/molecules24122266

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