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Open AccessArticle

Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process

Department of Chemical Engineering, Ming Chi University of Technology 84 Gungjuan Rd., Taishan Dist., New Taipei City 24301, Taiwan
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Author to whom correspondence should be addressed.
Academic Editor: Toshitaka Funazukuri
Molecules 2019, 24(12), 2235; https://doi.org/10.3390/molecules24122235
Received: 30 April 2019 / Revised: 11 June 2019 / Accepted: 14 June 2019 / Published: 14 June 2019
(This article belongs to the Special Issue Supercritical Fluids and Green Chemistry)
Polyethylene glycol (PEG) particles were prepared using low-temperature supercritical assisted atomization (LTSAA) with carbon dioxide as the spraying medium or the co-solute and acetone as the solvent. The effects of several key factors on the particle size were investigated. These factors included the concentration of the PEG solution, precipitator temperature, saturator temperature, ratio of the volumetric flow rate of carbon dioxide to the PEG solution, and the molecular weight of PEG. Spherical and non-aggregated PEG particles, with a mean size of 1.7–3.2 µm, were obtained in this study. The optimal conditions to produce fine particles were found to be a low concentration of the PEG solution, a low precipitator temperature, and low molecular weight of the PEG. The phase behavior of the solution mixture in the saturator presented a qualitative relationship. At the optimized volumetric flow rate ratios, the composition of CO2 in the feed streams was near the bubble points of the saturator temperatures. X-ray and differential scanning calorimetry analyses indicated that LTSAA-treated PEG had a reduced degree of crystallinity, which could be modulated via the precipitator temperature. PEG microparticles prepared by a LTSAA process would be promising carriers for drug-controlled formulations of PEG-drug composite particles. View Full-Text
Keywords: low-temperature supercritical assisted atomization; polyethylene glycol low-temperature supercritical assisted atomization; polyethylene glycol
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Wu, H.-T.; Tsai, H.-M.; Li, T.-H. Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process. Molecules 2019, 24, 2235.

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