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Open AccessArticle

Four New Flavonoids Isolated from the Aerial Parts of Cadaba rotundifolia Forssk. (Qadab)

1
Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
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Department of Pharmacognosy, College of Pharmacy, King Saud University, 11495 Riyadh, Saudi Arabia
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Department of Biology, Umm Al-Qura University, 1109 Makkah Al-Mukarramah, Saudi Arabia
4
Department of Biology, Arts and Sciences in Qilwah, Al-Baha University, 1988 Al-Baha, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Academic Editor: Francesco Epifano
Molecules 2019, 24(11), 2167; https://doi.org/10.3390/molecules24112167
Received: 19 May 2019 / Revised: 5 June 2019 / Accepted: 6 June 2019 / Published: 9 June 2019
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
Cadaba rotundifolia (Forssk.) (family: Capparaceae; common name: Qadab) is one of four species that grow in the Red Sea costal region in the Kingdom of Saudi Arabia. The roots and leaves of C. rotundifolia is traditionally used to treat tumors and abscesses in Sudan. A previous phytochemical study of the roots yielded a quaternary alkaloid, but no report on chemical constituents of the aerial parts of the C. rotundifolia growing in Saudi Arabia has been issued so far. Oxidative stress and advanced glycation end products (AGEs) are thought as causal factors in many degenerative diseases, such as Alzheimer’s disease, diabetes, atherosclerosis and aging. In this study, a total of twenty compounds, including four previously undescribed acylated kaempferol glucosides, were isolated from the aerial parts of C. rotundifolia collected in Saudi Arabia. These new compounds were identified as kaempferol 3-O-[2-O-(trans-feruloyl)-3-O-β-d-glucopyranosyl]-β-d-glucopyranoside (1), kaempferol 3-O-β-neohesperidoside-7-O-[2-O-(cis-p-coumaroyl)-3-O-β-d-glucopyranosyl]-β-d-glucopyranoside (2), kaempferol 3-O-[2,6-di-O-α-l-rhamnopyranosyl]-β-d-glucopyranoside-7-O-[6-O-(trans-feruloyl)]-β-d-glucopyranoside (3) and kaempferol 3-O-[2,6-di-O-α-l-rhamnopyranosyl]-β-d-glucopyranoside-7-O-[6-O-(trans-p-coumaroyl)]-β-d-glucopyranoside (4). Their structures were established based on UV-visible, 1D, 2D NMR, and HR-ESI-MS analyses. Of the assayed compounds, 17 and 18 showed potent radical scavenging activity with IC50 values of 14.5 and 11.7 µM, respectively, and inhibitory activity toward AGEs together with compound 7 with IC50 values 96.5, 34.9 and 85.5 µM, respectively. View Full-Text
Keywords: Cadaba rotundifolia; Capparaceae; Qadab; aerial parts; flavonoid; antioxidant; AGEs Cadaba rotundifolia; Capparaceae; Qadab; aerial parts; flavonoid; antioxidant; AGEs
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MDPI and ACS Style

Abdulaziz Al-Hamoud, G.; Saud Orfali, R.; Sugimoto, S.; Yamano, Y.; Alothyqi, N.; Mohammed Alzahrani, A.; Matsunami, K. Four New Flavonoids Isolated from the Aerial Parts of Cadaba rotundifolia Forssk. (Qadab). Molecules 2019, 24, 2167.

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