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Molecules 2019, 24(1), 27; https://doi.org/10.3390/molecules24010027

Direct Experimental Evidence of Biomimetic Surfaces with Chemical Modifications Interfering with Adhesive Protein Adsorption

1
CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
2
Laboratory of Microfabrication, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
3
Biolin Scientific (Shanghai) Trading Company Ltd., Shanghai 201203, China
*
Author to whom correspondence should be addressed.
Received: 2 December 2018 / Revised: 18 December 2018 / Accepted: 19 December 2018 / Published: 21 December 2018
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Abstract

Current approaches to dealing with the worldwide problem of marine biofouling are to impart chemical functionality to the surface or utilize microtopography inspired by nature. Previous reports have shown that only introducing a single method may not resist adhesion of mussels or inhibit biofouling in static forms. While it is promising to integrate two methods to develop an effective antifouling strategy, related basic research is still lacking. Here, we have fabricated engineered shark skin surfaces with different feature heights and terminated with different chemical moieties. Atomic force microscopy (AFM) with a modified colloid probe technique and quartz crystal microbalance with a dissipation n (QCM-D) monitoring method have been introduced to directly determine the interactions between adhesive proteins and functionalized surfaces. Our results indicate that the adhesion strength of probe-surface decreases with increasing feature height, and it also decreases from bare Si surface to alkyl and hydroxyl modification, which is attributed to different contact area domains and interaction mechanisms. Combining biomimetic microtopography and surface chemistry, our study provides a new perspective for designing and developing underwater anti-fouling materials. View Full-Text
Keywords: biomimetic surface; chemical modification; direct measurement; anti-fouling property; adhesive protein biomimetic surface; chemical modification; direct measurement; anti-fouling property; adhesive protein
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yang, H.; Zhang, W.; Chen, T.; Huang, S.; Quan, B.; Wang, M.; Li, J.; Gu, C.; Wang, J. Direct Experimental Evidence of Biomimetic Surfaces with Chemical Modifications Interfering with Adhesive Protein Adsorption. Molecules 2019, 24, 27.

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